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- W2904443864 abstract "An overdose of acetaminophen (APAP) causes liver injury through formation of N-acetyl-p-benzoquinoneimine, which overproduces reactive oxygen species (ROS). Autophagy maintains cellular homeostasis and is regulated by generation of ROS. Pterostilbene (PTE) has been shown to have antioxidant and anti-inflammatory properties. In this study, we investigated the protective mechanisms of PTE against APAP-induced liver injury, focusing on autophagy. ICR mice were intraperitoneally (i.p.) treated with 400 mg/kg of APAP. PTE (15, 30, and 60 mg/kg, i.p.) and chloroquine (CQ, 60 mg/kg, i.p.) were injected 1 h after APAP treatment. Blood and liver tissues were isolated 6 h after APAP treatment. PTE decreased serum aminotransferase activities and hepatic oxidative stress; this protective effect was abolished by CQ. APAP impaired autophagic flux, as evidenced by increased microtubule-associated protein-1 light chain 3-II and p62 protein expression; this impaired autophagic flux was restored by PTE, while CQ abolished this effect. APAP decreased beclin-1 and autophagy related protein 7 protein expressions, while PTE attenuated these decreases. PTE increased the lysosome-associated membrane protein-2 protein expression and decreased the mammalian target of rapamycin and Unc-51 like autophagy activating kinase 1 phosphorylation. Our findings suggest that PTE protects against APAP-induced hepatotoxicity by enhancing autophagic flux." @default.
- W2904443864 created "2018-12-22" @default.
- W2904443864 creator A5020609483 @default.
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- W2904443864 date "2019-01-01" @default.
- W2904443864 modified "2023-10-05" @default.
- W2904443864 title "Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux" @default.
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- W2904443864 doi "https://doi.org/10.1016/j.fct.2018.12.012" @default.
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- W2904443864 hasPublicationYear "2019" @default.
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