FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904454041> ?p ?o ?g. }

• W2904454041 endingPage "e0208453" @default.
• W2904454041 startingPage "e0208453" @default.
• W2904454041 abstract "Therapeutic hypothermia is a strategy that reduces metabolic rate and brain damage during clinically-relevant hypoxic events. Mitochondrial respiration is compromised by hypoxia, with deleterious consequences for the mammalian brain; however, little is known about the effects of reduced temperature on mitochondrial metabolism. Therefore, we examined how mitochondrial function is impacted by temperature using high resolution respirometry to assess electron transport system (ETS) function in saponin-permeabilized mouse brain at 28 and 37°C. Respirometric analysis revealed that, at the colder temperature, ETS respiratory flux was ~ 40–75% lower relative to the physiological temperature in all respiratory states and for all fuel substrates tested. In whole brain tissue, the enzyme maximum respiratory rates for complexes I-V were similarly reduced by between 37–88%. Complexes II and V were particularly temperature-sensitive; a temperature-mediated decrease in complex II activity may support a switch to complex I mediated ATP-production, which is considerably more oxygen-efficient. Finally, the mitochondrial H+-gradient was more tightly coupled, indicating that mitochondrial respiration is more efficient at the colder temperature. Taken together, our results suggest that improvements in mitochondrial function with colder temperatures may contribute to energy conservation and enhance cellular viability in hypoxic brain." @default.
• W2904454041 created "2018-12-22" @default.
• W2904454041 creator A5031927070 @default.
• W2904454041 creator A5046304119 @default.
• W2904454041 creator A5071728431 @default.
• W2904454041 date "2018-12-06" @default.
• W2904454041 modified "2023-09-26" @default.
• W2904454041 title "Effects of cold on murine brain mitochondrial function" @default.
• W2904454041 cites W102545237 @default.
• W2904454041 cites W1972398452 @default.
• W2904454041 cites W1975987540 @default.
• W2904454041 cites W1977161523 @default.
• W2904454041 cites W1990242715 @default.
• W2904454041 cites W1992011928 @default.
• W2904454041 cites W1994163335 @default.
• W2904454041 cites W2000295349 @default.
• W2904454041 cites W2008214949 @default.
• W2904454041 cites W2023656275 @default.
• W2904454041 cites W2031184838 @default.
• W2904454041 cites W2043641626 @default.
• W2904454041 cites W2054937705 @default.
• W2904454041 cites W2056243673 @default.
• W2904454041 cites W2057962542 @default.
• W2904454041 cites W2086984623 @default.
• W2904454041 cites W2098764985 @default.
• W2904454041 cites W2113912003 @default.
• W2904454041 cites W2120924986 @default.
• W2904454041 cites W2122091775 @default.
• W2904454041 cites W2128635872 @default.
• W2904454041 cites W2139921047 @default.
• W2904454041 cites W2158101029 @default.
• W2904454041 cites W2159736959 @default.
• W2904454041 cites W2175761811 @default.
• W2904454041 cites W2233018270 @default.
• W2904454041 cites W2578292641 @default.
• W2904454041 cites W2617068912 @default.
• W2904454041 cites W2729188489 @default.
• W2904454041 cites W2730697691 @default.
• W2904454041 cites W2734725170 @default.
• W2904454041 cites W2765230669 @default.
• W2904454041 cites W2770872189 @default.
• W2904454041 cites W2777359387 @default.
• W2904454041 cites W2779033652 @default.
• W2904454041 cites W2791825018 @default.
• W2904454041 cites W2950530527 @default.
• W2904454041 cites W4293247451 @default.
• W2904454041 doi "https://doi.org/10.1371/journal.pone.0208453" @default.
• W2904454041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6283463" @default.
• W2904454041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30521596" @default.
• W2904454041 hasPublicationYear "2018" @default.
• W2904454041 type Work @default.
• W2904454041 sameAs 2904454041 @default.
• W2904454041 citedByCount "14" @default.
• W2904454041 countsByYear W29044540412019 @default.
• W2904454041 countsByYear W29044540412020 @default.
• W2904454041 countsByYear W29044540412021 @default.
• W2904454041 countsByYear W29044540412022 @default.
• W2904454041 countsByYear W29044540412023 @default.
• W2904454041 crossrefType "journal-article" @default.
• W2904454041 hasAuthorship W2904454041A5031927070 @default.
• W2904454041 hasAuthorship W2904454041A5046304119 @default.
• W2904454041 hasAuthorship W2904454041A5071728431 @default.
• W2904454041 hasBestOaLocation W29044540411 @default.
• W2904454041 hasConcept C100206155 @default.
• W2904454041 hasConcept C105702510 @default.
• W2904454041 hasConcept C12554922 @default.
• W2904454041 hasConcept C165135838 @default.
• W2904454041 hasConcept C178790620 @default.
• W2904454041 hasConcept C182215343 @default.
• W2904454041 hasConcept C185592680 @default.
• W2904454041 hasConcept C24840226 @default.
• W2904454041 hasConcept C2777390192 @default.
• W2904454041 hasConcept C28859421 @default.
• W2904454041 hasConcept C42407357 @default.
• W2904454041 hasConcept C534529494 @default.
• W2904454041 hasConcept C540031477 @default.
• W2904454041 hasConcept C55493867 @default.
• W2904454041 hasConcept C62231903 @default.
• W2904454041 hasConcept C66517615 @default.
• W2904454041 hasConcept C68394932 @default.
• W2904454041 hasConcept C7836513 @default.
• W2904454041 hasConcept C86803240 @default.
• W2904454041 hasConcept C95444343 @default.
• W2904454041 hasConceptScore W2904454041C100206155 @default.
• W2904454041 hasConceptScore W2904454041C105702510 @default.
• W2904454041 hasConceptScore W2904454041C12554922 @default.
• W2904454041 hasConceptScore W2904454041C165135838 @default.
• W2904454041 hasConceptScore W2904454041C178790620 @default.
• W2904454041 hasConceptScore W2904454041C182215343 @default.
• W2904454041 hasConceptScore W2904454041C185592680 @default.
• W2904454041 hasConceptScore W2904454041C24840226 @default.
• W2904454041 hasConceptScore W2904454041C2777390192 @default.
• W2904454041 hasConceptScore W2904454041C28859421 @default.
• W2904454041 hasConceptScore W2904454041C42407357 @default.
• W2904454041 hasConceptScore W2904454041C534529494 @default.
• W2904454041 hasConceptScore W2904454041C540031477 @default.
• W2904454041 hasConceptScore W2904454041C55493867 @default.
• W2904454041 hasConceptScore W2904454041C62231903 @default.

• next