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• W2904454047 abstract "To gain a new insight into the role of proteins in the origin of life on Earth, we present the Janus Challenge: identify an intrinsically disordered protein (IDP), naturally occurring or synthetic, that has catalytic activity. For example, such a catalytic IDP may perform condensation reactions to catalyze a peptide bond or a phosphodiester bond formation utilizing natural/un-natural amino acids or nucleotides, respectively. The IDP may also have autocatalytic, de novo synthesis, or self-replicative activity. Meeting this challenge may not only shed new light and provide an alternative to the RNA world hypothesis, but it may also serve as an impetus for technological advances with important biomedical applications." @default.
• W2904454047 created "2018-12-22" @default.
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• W2904454047 date "2018-12-18" @default.
• W2904454047 modified "2023-09-24" @default.
• W2904454047 title "Intrinsically Disordered Proteins and the Janus Challenge" @default.
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• W2904454047 doi "https://doi.org/10.3390/biom8040179" @default.
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