FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904459349> ?p ?o ?g. }

• W2904459349 endingPage "18.2018" @default.
• W2904459349 startingPage "ENEURO.0402" @default.
• W2904459349 abstract "Abstract BDNF is a critical contributor to neuronal growth, development, learning, and memory. Although extensively studied in the brain, BDNF is also expressed by primary afferent sensory neurons in the peripheral nervous system. Unfortunately, anatomical and functional studies of primary afferent-derived BDNF have been limited by the availability of appropriate molecular tools. Here, we used targeted, inducible molecular approaches to characterize the expression pattern of primary afferent BDNF and the extent to which it contributes to a variety of pain and itch behaviors. Using a BDNF-LacZ reporter mouse, we found that BDNF is expressed primarily by myelinated primary afferents and has limited overlap with the major peptidergic and non-peptidergic subclasses of nociceptors and pruritoceptors. We also observed extensive neuronal, but not glial, expression in the spinal cord dorsal horn. In addition, because BDNF null mice are not viable and even Cre-mediated deletion of BDNF from sensory neurons could have developmental consequences, here we deleted BDNF selectively from sensory neurons, in the adult, using an advillin-Cre-ER line crossed to floxed BDNF mice. We found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests. Based on the anatomical distribution of sensory neuron-derived BDNF and its limited contribution to pain and itch processing, we suggest that future studies of primary afferent-derived BDNF should examine behaviors evoked by activation of myelinated primary afferents." @default.
• W2904459349 created "2018-12-22" @default.
• W2904459349 creator A5007740596 @default.
• W2904459349 creator A5008503327 @default.
• W2904459349 creator A5051772462 @default.
• W2904459349 creator A5066725458 @default.
• W2904459349 creator A5084440429 @default.
• W2904459349 date "2018-11-01" @default.
• W2904459349 modified "2023-10-18" @default.
• W2904459349 title "Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch" @default.
• W2904459349 cites W1551383644 @default.
• W2904459349 cites W1555679702 @default.
• W2904459349 cites W1568010017 @default.
• W2904459349 cites W1635709196 @default.
• W2904459349 cites W1897402702 @default.
• W2904459349 cites W1914763441 @default.
• W2904459349 cites W1979075898 @default.
• W2904459349 cites W1980360344 @default.
• W2904459349 cites W1985842189 @default.
• W2904459349 cites W1992832141 @default.
• W2904459349 cites W1999370442 @default.
• W2904459349 cites W2002473696 @default.
• W2904459349 cites W2004901620 @default.
• W2904459349 cites W2012265686 @default.
• W2904459349 cites W2022745333 @default.
• W2904459349 cites W2024182346 @default.
• W2904459349 cites W2028475553 @default.
• W2904459349 cites W2030076800 @default.
• W2904459349 cites W2033841060 @default.
• W2904459349 cites W2038381968 @default.
• W2904459349 cites W2038765440 @default.
• W2904459349 cites W2048911253 @default.
• W2904459349 cites W2049938995 @default.
• W2904459349 cites W2051675716 @default.
• W2904459349 cites W2054275187 @default.
• W2904459349 cites W2055541457 @default.
• W2904459349 cites W2067040581 @default.
• W2904459349 cites W2075449089 @default.
• W2904459349 cites W2076894554 @default.
• W2904459349 cites W2086046914 @default.
• W2904459349 cites W2086866828 @default.
• W2904459349 cites W2095818818 @default.
• W2904459349 cites W2110442840 @default.
• W2904459349 cites W2113138572 @default.
• W2904459349 cites W2117830068 @default.
• W2904459349 cites W2126416149 @default.
• W2904459349 cites W2128994172 @default.
• W2904459349 cites W2133138877 @default.
• W2904459349 cites W2140507103 @default.
• W2904459349 cites W2143654625 @default.
• W2904459349 cites W2146742867 @default.
• W2904459349 cites W2153968156 @default.
• W2904459349 cites W2155524482 @default.
• W2904459349 cites W2157226283 @default.
• W2904459349 cites W2166528578 @default.
• W2904459349 cites W2201999685 @default.
• W2904459349 cites W2230139149 @default.
• W2904459349 cites W2556658320 @default.
• W2904459349 cites W2560421166 @default.
• W2904459349 cites W2776476861 @default.
• W2904459349 cites W2780278237 @default.
• W2904459349 doi "https://doi.org/10.1523/eneuro.0402-18.2018" @default.
• W2904459349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6325548" @default.
• W2904459349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30627644" @default.
• W2904459349 hasPublicationYear "2018" @default.
• W2904459349 type Work @default.
• W2904459349 sameAs 2904459349 @default.
• W2904459349 citedByCount "24" @default.
• W2904459349 countsByYear W29044593492019 @default.
• W2904459349 countsByYear W29044593492020 @default.
• W2904459349 countsByYear W29044593492021 @default.
• W2904459349 countsByYear W29044593492022 @default.
• W2904459349 countsByYear W29044593492023 @default.
• W2904459349 crossrefType "journal-article" @default.
• W2904459349 hasAuthorship W2904459349A5007740596 @default.
• W2904459349 hasAuthorship W2904459349A5008503327 @default.
• W2904459349 hasAuthorship W2904459349A5051772462 @default.
• W2904459349 hasAuthorship W2904459349A5066725458 @default.
• W2904459349 hasAuthorship W2904459349A5084440429 @default.
• W2904459349 hasBestOaLocation W29044593491 @default.
• W2904459349 hasConcept C126322002 @default.
• W2904459349 hasConcept C15490471 @default.
• W2904459349 hasConcept C15744967 @default.
• W2904459349 hasConcept C160539049 @default.
• W2904459349 hasConcept C169760540 @default.
• W2904459349 hasConcept C170493617 @default.
• W2904459349 hasConcept C172659308 @default.
• W2904459349 hasConcept C2778790584 @default.
• W2904459349 hasConcept C2779263132 @default.
• W2904459349 hasConcept C2780775167 @default.
• W2904459349 hasConcept C71924100 @default.
• W2904459349 hasConcept C86803240 @default.
• W2904459349 hasConcept C94487597 @default.
• W2904459349 hasConceptScore W2904459349C126322002 @default.
• W2904459349 hasConceptScore W2904459349C15490471 @default.
• W2904459349 hasConceptScore W2904459349C15744967 @default.
• W2904459349 hasConceptScore W2904459349C160539049 @default.
• W2904459349 hasConceptScore W2904459349C169760540 @default.

• next