FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904467407> ?p ?o ?g. }

• W2904467407 abstract "Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood. Using single receptor-deficient platelets from TAM knockout mice in the C57BL/6 J strain, we performed a knockout study using single TAM-deficient mice. We treated platelets isolated from TAM knockout mice with the Glycoprotein VI (GPVI) agonists convulxin, poly(PHG), and collagen-related triple-helical peptide (CRP), as well as thrombin for in-vitro experiments. We used a laser-induced cremaster arterial injury model for thrombosis experiments in vivo. Deficiency of the tyrosine kinase receptors, Axl or Tyro3, but not Mertk, inhibited aggregation, spreading, JON/A binding, and P-selectin expression of platelets in vitro. In vivo, platelet thrombus formation was significantly decreased in Axl−/− and Tyro3−/− mice, but not in Mertk−/− mice. Upon stimulation with glycoprotein VI (GPVI) agonists, tyrosine phosphorylation of signaling molecules, including spleen tyrosine kinase (Syk) and phospholipase C-γ2 (PLCγ2), was decreased in Axl−/− and Tyro3−/− platelets, but not in Mertk−/− platelets. While platelet aggregation induced by agonists did not differ in the presence or absence of the Gas6 neutralizing antibody, the platelet aggregation was inhibited by anti-Axl or anti-Tyro3 neutralizing antibodies antibody, but not the anti-Mertk antibody. Additionally, the recombinant extracellular domain of Axl or Tyro3, but not that of Mertk, also inhibited platelet aggregation. These data suggest that Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation, and mechanistically may do so by a pathway that regulates inside to outside signaling and heterotypic interactions via the extracellular domains of TAMs." @default.
• W2904467407 created "2018-12-22" @default.
• W2904467407 creator A5009932116 @default.
• W2904467407 creator A5026593351 @default.
• W2904467407 creator A5037540927 @default.
• W2904467407 creator A5039027509 @default.
• W2904467407 creator A5045935466 @default.
• W2904467407 creator A5054933332 @default.
• W2904467407 creator A5063033245 @default.
• W2904467407 creator A5063809151 @default.
• W2904467407 creator A5065417461 @default.
• W2904467407 creator A5069721725 @default.
• W2904467407 creator A5076647158 @default.
• W2904467407 date "2018-12-01" @default.
• W2904467407 modified "2023-10-17" @default.
• W2904467407 title "Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation" @default.
• W2904467407 cites W1498260212 @default.
• W2904467407 cites W1646925026 @default.
• W2904467407 cites W166833621 @default.
• W2904467407 cites W1888503564 @default.
• W2904467407 cites W1896366405 @default.
• W2904467407 cites W1913624400 @default.
• W2904467407 cites W1935672226 @default.
• W2904467407 cites W1954516783 @default.
• W2904467407 cites W1966123096 @default.
• W2904467407 cites W1967664376 @default.
• W2904467407 cites W1972832497 @default.
• W2904467407 cites W1975086118 @default.
• W2904467407 cites W1986020802 @default.
• W2904467407 cites W1996031638 @default.
• W2904467407 cites W2008423937 @default.
• W2904467407 cites W2012165211 @default.
• W2904467407 cites W2015356339 @default.
• W2904467407 cites W2018190963 @default.
• W2904467407 cites W2021156311 @default.
• W2904467407 cites W2028746948 @default.
• W2904467407 cites W2028888447 @default.
• W2904467407 cites W2030297681 @default.
• W2904467407 cites W2035400134 @default.
• W2904467407 cites W2036571449 @default.
• W2904467407 cites W2038122505 @default.
• W2904467407 cites W2040434188 @default.
• W2904467407 cites W2051564951 @default.
• W2904467407 cites W2051677654 @default.
• W2904467407 cites W2056601905 @default.
• W2904467407 cites W2057410086 @default.
• W2904467407 cites W2062620427 @default.
• W2904467407 cites W2069387668 @default.
• W2904467407 cites W2073593898 @default.
• W2904467407 cites W2087411946 @default.
• W2904467407 cites W2087807120 @default.
• W2904467407 cites W2088234703 @default.
• W2904467407 cites W2088919516 @default.
• W2904467407 cites W2098068533 @default.
• W2904467407 cites W2100021081 @default.
• W2904467407 cites W2101909393 @default.
• W2904467407 cites W2106322567 @default.
• W2904467407 cites W2109503431 @default.
• W2904467407 cites W2117077088 @default.
• W2904467407 cites W2117511143 @default.
• W2904467407 cites W2118971976 @default.
• W2904467407 cites W2126799091 @default.
• W2904467407 cites W2133902177 @default.
• W2904467407 cites W2137108685 @default.
• W2904467407 cites W2153326117 @default.
• W2904467407 cites W2162436188 @default.
• W2904467407 cites W2165178980 @default.
• W2904467407 cites W2165868580 @default.
• W2904467407 cites W2171143508 @default.
• W2904467407 cites W2289617846 @default.
• W2904467407 cites W2312810378 @default.
• W2904467407 cites W2312951294 @default.
• W2904467407 cites W2410300187 @default.
• W2904467407 cites W242818551 @default.
• W2904467407 cites W2586117957 @default.
• W2904467407 cites W2621264327 @default.
• W2904467407 cites W69487149 @default.
• W2904467407 doi "https://doi.org/10.1186/s12964-018-0308-0" @default.
• W2904467407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6291976" @default.
• W2904467407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30541554" @default.
• W2904467407 hasPublicationYear "2018" @default.
• W2904467407 type Work @default.
• W2904467407 sameAs 2904467407 @default.
• W2904467407 citedByCount "18" @default.
• W2904467407 countsByYear W29044674072019 @default.
• W2904467407 countsByYear W29044674072020 @default.
• W2904467407 countsByYear W29044674072021 @default.
• W2904467407 countsByYear W29044674072022 @default.
• W2904467407 countsByYear W29044674072023 @default.
• W2904467407 crossrefType "journal-article" @default.
• W2904467407 hasAuthorship W2904467407A5009932116 @default.
• W2904467407 hasAuthorship W2904467407A5026593351 @default.
• W2904467407 hasAuthorship W2904467407A5037540927 @default.
• W2904467407 hasAuthorship W2904467407A5039027509 @default.
• W2904467407 hasAuthorship W2904467407A5045935466 @default.
• W2904467407 hasAuthorship W2904467407A5054933332 @default.
• W2904467407 hasAuthorship W2904467407A5063033245 @default.
• W2904467407 hasAuthorship W2904467407A5063809151 @default.
• W2904467407 hasAuthorship W2904467407A5065417461 @default.
• W2904467407 hasAuthorship W2904467407A5069721725 @default.

• next