FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904468693> ?p ?o ?g. }

• W2904468693 endingPage "318" @default.
• W2904468693 startingPage "313" @default.
• W2904468693 abstract "Acidic soils, where aluminum (Al) toxicity is a major agricultural constraint, are globally widespread and are prevalent in developing countries. In sorghum, the root citrate transporter SbMATE confers Al tolerance by protecting root apices from toxic Al 3+ , but can exhibit reduced expression when introgressed into different lines. We show that allele-specific SbMATE transactivation occurs and is caused by factors located away from SbMATE . Using expression-QTL mapping and expression genome-wide association mapping, we establish that SbMATE transcription is controlled in a bipartite fashion, primarily in cis but also in trans . Multiallelic promoter transactivation and ChIP analyses demonstrated that intermolecular effects on SbMATE expression arise from a WRKY and a zinc finger-DHHC transcription factor (TF) that bind to and trans -activate the SbMATE promoter. A haplotype analysis in sorghum RILs indicates that the TFs influence SbMATE expression and Al tolerance. Variation in SbMATE expression likely results from changes in tandemly repeated cis sequences flanking a transposable element (a miniature inverted repeat transposable element) insertion in the SbMATE promoter, which are recognized by the Al 3+ -responsive TFs. According to our model, repeat expansion in Al-tolerant genotypes increases TF recruitment and, hence, SbMATE expression, which is, in turn, lower in Al-sensitive genetic backgrounds as a result of lower TF expression and fewer binding sites. We thus show that even dominant cis regulation of an agronomically important gene can be subjected to precise intermolecular fine-tuning. These concerted c is / trans interactions, which allow the plant to sense and respond to environmental cues, such as Al 3+ toxicity, can now be used to increase yields and food security on acidic soils." @default.
• W2904468693 created "2018-12-22" @default.
• W2904468693 creator A5010001905 @default.
• W2904468693 creator A5013577051 @default.
• W2904468693 creator A5034833249 @default.
• W2904468693 creator A5041089155 @default.
• W2904468693 creator A5044378337 @default.
• W2904468693 creator A5048503989 @default.
• W2904468693 creator A5050367915 @default.
• W2904468693 creator A5053543995 @default.
• W2904468693 creator A5054793538 @default.
• W2904468693 creator A5065062452 @default.
• W2904468693 creator A5067628813 @default.
• W2904468693 creator A5091240438 @default.
• W2904468693 date "2018-12-13" @default.
• W2904468693 modified "2023-10-16" @default.
• W2904468693 title "Repeat variants for the SbMATE transporter protect sorghum roots from aluminum toxicity by transcriptional interplay in<i>cis</i>and<i>trans</i>" @default.
• W2904468693 cites W1968376884 @default.
• W2904468693 cites W1975421091 @default.
• W2904468693 cites W1977194988 @default.
• W2904468693 cites W1987504527 @default.
• W2904468693 cites W1991948589 @default.
• W2904468693 cites W2005019160 @default.
• W2904468693 cites W2029570887 @default.
• W2904468693 cites W2093922969 @default.
• W2904468693 cites W2095035334 @default.
• W2904468693 cites W2095295625 @default.
• W2904468693 cites W2126822473 @default.
• W2904468693 cites W2131690896 @default.
• W2904468693 cites W2140624038 @default.
• W2904468693 cites W2146133538 @default.
• W2904468693 cites W2164676096 @default.
• W2904468693 cites W2167066339 @default.
• W2904468693 cites W2167288238 @default.
• W2904468693 cites W2267628831 @default.
• W2904468693 cites W2528951128 @default.
• W2904468693 cites W2581745547 @default.
• W2904468693 cites W4247734158 @default.
• W2904468693 doi "https://doi.org/10.1073/pnas.1808400115" @default.
• W2904468693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6320528" @default.
• W2904468693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30545913" @default.
• W2904468693 hasPublicationYear "2018" @default.
• W2904468693 type Work @default.
• W2904468693 sameAs 2904468693 @default.
• W2904468693 citedByCount "32" @default.
• W2904468693 countsByYear W29044686932019 @default.
• W2904468693 countsByYear W29044686932020 @default.
• W2904468693 countsByYear W29044686932021 @default.
• W2904468693 countsByYear W29044686932022 @default.
• W2904468693 countsByYear W29044686932023 @default.
• W2904468693 crossrefType "journal-article" @default.
• W2904468693 hasAuthorship W2904468693A5010001905 @default.
• W2904468693 hasAuthorship W2904468693A5013577051 @default.
• W2904468693 hasAuthorship W2904468693A5034833249 @default.
• W2904468693 hasAuthorship W2904468693A5041089155 @default.
• W2904468693 hasAuthorship W2904468693A5044378337 @default.
• W2904468693 hasAuthorship W2904468693A5048503989 @default.
• W2904468693 hasAuthorship W2904468693A5050367915 @default.
• W2904468693 hasAuthorship W2904468693A5053543995 @default.
• W2904468693 hasAuthorship W2904468693A5054793538 @default.
• W2904468693 hasAuthorship W2904468693A5065062452 @default.
• W2904468693 hasAuthorship W2904468693A5067628813 @default.
• W2904468693 hasAuthorship W2904468693A5091240438 @default.
• W2904468693 hasBestOaLocation W29044686931 @default.
• W2904468693 hasConcept C101762097 @default.
• W2904468693 hasConcept C104317684 @default.
• W2904468693 hasConcept C1292079 @default.
• W2904468693 hasConcept C141231307 @default.
• W2904468693 hasConcept C150194340 @default.
• W2904468693 hasConcept C158448853 @default.
• W2904468693 hasConcept C162317418 @default.
• W2904468693 hasConcept C4918238 @default.
• W2904468693 hasConcept C54355233 @default.
• W2904468693 hasConcept C79877727 @default.
• W2904468693 hasConcept C86339819 @default.
• W2904468693 hasConcept C86803240 @default.
• W2904468693 hasConceptScore W2904468693C101762097 @default.
• W2904468693 hasConceptScore W2904468693C104317684 @default.
• W2904468693 hasConceptScore W2904468693C1292079 @default.
• W2904468693 hasConceptScore W2904468693C141231307 @default.
• W2904468693 hasConceptScore W2904468693C150194340 @default.
• W2904468693 hasConceptScore W2904468693C158448853 @default.
• W2904468693 hasConceptScore W2904468693C162317418 @default.
• W2904468693 hasConceptScore W2904468693C4918238 @default.
• W2904468693 hasConceptScore W2904468693C54355233 @default.
• W2904468693 hasConceptScore W2904468693C79877727 @default.
• W2904468693 hasConceptScore W2904468693C86339819 @default.
• W2904468693 hasConceptScore W2904468693C86803240 @default.
• W2904468693 hasFunder F4320321675 @default.
• W2904468693 hasFunder F4320322025 @default.
• W2904468693 hasFunder F4320322980 @default.
• W2904468693 hasIssue "1" @default.
• W2904468693 hasLocation W29044686931 @default.
• W2904468693 hasLocation W29044686932 @default.
• W2904468693 hasLocation W29044686933 @default.
• W2904468693 hasLocation W29044686934 @default.
• W2904468693 hasLocation W29044686935 @default.
• W2904468693 hasOpenAccess W2904468693 @default.

• next