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• W2904481034 abstract "Ever since daptomycin was introduced to the clinic, daptomycin-resistant isolates have been reported. In most cases, the resistant isolates harbor point mutations in MprF, which produces and flips the positively charged phospholipid LysPG. This has led to the assumption that the resistance mechanism relies on the overproduction of LysPG, given that increased LysPG production may lead to increased electrostatic repulsion of positively charged antimicrobial compounds, including daptomycin. Here we show that the resistance mechanism is highly specific and relies on a different process that involves a functional MprF flippase, suggesting that the resistance-conferring mutations may enable the flippase to accommodate daptomycin or an unknown component that is crucial for its activity. Our report provides a new perspective on the mechanism of resistance to a major antibiotic." @default.
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• W2904481034 date "2018-12-21" @default.
• W2904481034 modified "2023-10-14" @default.
• W2904481034 title "Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance" @default.
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• W2904481034 doi "https://doi.org/10.1128/mbio.01659-18" @default.
• W2904481034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299216" @default.
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• W2904481034 hasPublicationYear "2018" @default.
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