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• W2904495087 abstract "Iron overload has been implicated in the pathogenesis of many neurodegenerative diseases, cancer and thalassemia. In this work, we have developed new supramolecular assemblies as potential iron chelators for mitigating iron overload at the cellular level. We utilized fluorenyl-based building blocks that were functionalized with ethylene diamine (Fmoc-Ed) or arginine (Fmoc-Arg). Fmoc-Ed was further conjugated with ureido propionic acid (UDP) or pyrazole-3-carboxylic acid (PCA). Each of the building blocks were self-assembled into nanovesicles or fibers and further functionalized with the transferrin receptor binding peptide THRPPMWSPVWP (Tf) to promote receptor mediated cellular uptake. Our results indicated that the assemblies were able to target HeLa cells, induce apoptosis, ROS formation and were able to penetrate the cells. The degree of cellular impact was dependent upon the structure of the assemblies. The effects were more prominent under iron overload conditions compared to normal growth conditions. Our results suggest that such nanoscale assemblies may open new avenues for further studies into iron chelation and mitigation of iron overload using Fmoc-functionalized building blocks." @default.
• W2904495087 created "2018-12-22" @default.
• W2904495087 creator A5031797084 @default.
• W2904495087 creator A5089576512 @default.
• W2904495087 date "2018-12-10" @default.
• W2904495087 modified "2023-09-27" @default.
• W2904495087 title "Development of new amphiphilic bio-organic assemblies for potential applications in iron-binding and targeting tumor cells" @default.
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• W2904495087 doi "https://doi.org/10.1080/1539445x.2018.1548357" @default.
• W2904495087 hasPublicationYear "2018" @default.
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