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- W2904503583 endingPage "33" @default.
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- W2904503583 abstract "Engineering and modifying synthetic microbial chassis is one of the best ways not only to unravel the fundamental principles of life but also to enhance applications in the health, medicine, agricultural, veterinary, and food industries. The two primary strategies for constructing a microbial chassis are the top-down approach (genome reduction) and the bottom-up approach (genome synthesis). Research programs on this topic have been funded in several countries. The 'Minimum genome factory' (MGF) project was launched in 2001 in Japan with the goal of constructing microorganisms with smaller genomes for industrial use. One of the best examples of the results of this project is E. coli MGF-01, which has a reduced-genome size and exhibits better growth and higher threonine production characteristics than the parental strain [1]. The 'cell factory' project was carried out from 1998 to 2002 in the Fifth Framework Program of the EU (European Union), which tried to comprehensively understand microorganisms used in the application field. One of the outstanding results of this project was the elucidation of proteins secreted by Bacillus subtilis, which was summarized as the 'secretome' [2]. The GTL (Genomes to Life) program began in 2002 in the United States. In this program, researchers aimed to create artificial cells both in silico and in vitro, such as the successful design and synthesis of a minimal bacterial genome by John Craig Venter's group [3]. This review provides an update on recent advances in engineering, modification and application of synthetic microbial chassis, with particular emphasis on the value of learning about chassis as a way to better understand life and improve applications." @default.
- W2904503583 created "2018-12-22" @default.
- W2904503583 creator A5007588252 @default.
- W2904503583 creator A5031213877 @default.
- W2904503583 creator A5039187009 @default.
- W2904503583 creator A5050419694 @default.
- W2904503583 creator A5058254184 @default.
- W2904503583 creator A5059228473 @default.
- W2904503583 creator A5087099599 @default.
- W2904503583 date "2019-03-01" @default.
- W2904503583 modified "2023-10-15" @default.
- W2904503583 title "Engineering and modification of microbial chassis for systems and synthetic biology" @default.
- W2904503583 cites W1501067566 @default.
- W2904503583 cites W1598992418 @default.
- W2904503583 cites W1651306755 @default.
- W2904503583 cites W1654506813 @default.
- W2904503583 cites W1845520455 @default.
- W2904503583 cites W1932877617 @default.
- W2904503583 cites W1936630560 @default.
- W2904503583 cites W1964717280 @default.
- W2904503583 cites W1970087240 @default.
- W2904503583 cites W1971439989 @default.
- W2904503583 cites W1972656778 @default.
- W2904503583 cites W1972915118 @default.
- W2904503583 cites W1973728570 @default.
- W2904503583 cites W1976391205 @default.
- W2904503583 cites W1977125035 @default.
- W2904503583 cites W1977739164 @default.
- W2904503583 cites W1978614878 @default.
- W2904503583 cites W1978668215 @default.
- W2904503583 cites W1984248485 @default.
- W2904503583 cites W1984504145 @default.
- W2904503583 cites W1986641657 @default.
- W2904503583 cites W1986796454 @default.
- W2904503583 cites W1988032281 @default.
- W2904503583 cites W1989443088 @default.
- W2904503583 cites W1992724663 @default.
- W2904503583 cites W1992981247 @default.
- W2904503583 cites W1996568337 @default.
- W2904503583 cites W2000004958 @default.
- W2904503583 cites W2002702150 @default.
- W2904503583 cites W2005082229 @default.
- W2904503583 cites W2005593959 @default.
- W2904503583 cites W2009156161 @default.
- W2904503583 cites W2010122109 @default.
- W2904503583 cites W2010698369 @default.
- W2904503583 cites W2015557312 @default.
- W2904503583 cites W2016315684 @default.
- W2904503583 cites W2017853763 @default.
- W2904503583 cites W2019779784 @default.
- W2904503583 cites W2021099440 @default.
- W2904503583 cites W2029579354 @default.
- W2904503583 cites W2035673487 @default.
- W2904503583 cites W2039295326 @default.
- W2904503583 cites W2043170430 @default.
- W2904503583 cites W2045103587 @default.
- W2904503583 cites W2045785445 @default.
- W2904503583 cites W2054920102 @default.
- W2904503583 cites W2057848231 @default.
- W2904503583 cites W2062736124 @default.
- W2904503583 cites W2064167559 @default.
- W2904503583 cites W2070615340 @default.
- W2904503583 cites W2074248917 @default.
- W2904503583 cites W2081418090 @default.
- W2904503583 cites W2084447564 @default.
- W2904503583 cites W2084832691 @default.
- W2904503583 cites W2086235848 @default.
- W2904503583 cites W2090367881 @default.
- W2904503583 cites W2102440675 @default.
- W2904503583 cites W2105618568 @default.
- W2904503583 cites W2108385415 @default.
- W2904503583 cites W2113860028 @default.
- W2904503583 cites W2115955653 @default.
- W2904503583 cites W2116629820 @default.
- W2904503583 cites W2116788456 @default.
- W2904503583 cites W2119025443 @default.
- W2904503583 cites W2120353169 @default.
- W2904503583 cites W2124208385 @default.
- W2904503583 cites W2124363431 @default.
- W2904503583 cites W2124703740 @default.
- W2904503583 cites W2125212058 @default.
- W2904503583 cites W2133091545 @default.
- W2904503583 cites W2134153749 @default.
- W2904503583 cites W2134370272 @default.
- W2904503583 cites W2135980271 @default.
- W2904503583 cites W2140055375 @default.
- W2904503583 cites W2141825087 @default.
- W2904503583 cites W2143999510 @default.
- W2904503583 cites W2149378314 @default.
- W2904503583 cites W2152843998 @default.
- W2904503583 cites W2153283265 @default.
- W2904503583 cites W2154835148 @default.
- W2904503583 cites W2157815481 @default.
- W2904503583 cites W2159916488 @default.
- W2904503583 cites W2220904888 @default.
- W2904503583 cites W2278253772 @default.
- W2904503583 cites W2291204809 @default.
- W2904503583 cites W2303398933 @default.