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- W2904503760 abstract "Extracorporeal membrane oxygenators are used in critical care for the management of severe respiratory and cardiac failure. Activation of the coagulation system is initiated by the exposure of blood to synthetic surfaces and the shear stresses of the circuit, especially from device pumps. Initial fibrinogen deposition and subsequent activation of coagulation factors and complement allow platelets and leucocytes to adhere to oxygenator surfaces and enhance thrombin generation. These changes and others contribute to higher rates of thrombosis seen in these patients. In addition, bleeding rates are also high. Primary haemostasis is impaired by platelet dysfunction and loss of their key adhesive molecules and shear stress causing an acquired von Willebrand defect. In addition, there is also altered fibrinolysis and lastly, administration of systemic anticoagulation is required to maintain circuit patency. Further research is required to fully establish the complexities of the haemostatic changes with these devices, and to elucidate the mechanistic changes that are mainly responsible so that plans can be made to reduce their complications and improve management." @default.
- W2904503760 created "2018-12-22" @default.
- W2904503760 creator A5032411762 @default.
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- W2904503760 date "2018-12-12" @default.
- W2904503760 modified "2023-10-10" @default.
- W2904503760 title "Current Understanding of How Extracorporeal Membrane Oxygenators Activate Haemostasis and Other Blood Components" @default.
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- W2904503760 doi "https://doi.org/10.3389/fmed.2018.00352" @default.
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