Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904505884> ?p ?o ?g. }
- W2904505884 endingPage "111" @default.
- W2904505884 startingPage "101" @default.
- W2904505884 abstract "To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer's disease (AD), and explore possible group differences in 11C-PIB binding to white matter.11C-PIB PET scans were acquired from subjects with AD (n=17) and healthy elderly controls (n=19). Voxel-based analysis was performed with statistical parametric mapping (SPM).Cerebellar normalization showed higher 11C-PIB uptake in the AD group relative to controls throughout the cerebral cortex, involving the lateral temporal, orbitofrontal, and superior parietal cortices. With global uptake normalization, greatest cortical binding was detected in the orbitofrontal cortex; decreased 11C-PIB uptake in white matter was found in the posterior hippocampal region, corpus callosum, pons, and internal capsule.The present case-control voxelwise 11C-PIB PET comparison highlighted the regional distribution of amyloid deposition in the cerebral cortex of mildly demented AD patients. Tracer uptake was highest in the orbitofrontal cortex. Decreased 11C-PIB uptake in white-matter regions in this patient population may be a marker of white-matter damage in AD." @default.
- W2904505884 created "2018-12-22" @default.
- W2904505884 creator A5007804149 @default.
- W2904505884 creator A5014555108 @default.
- W2904505884 creator A5024192961 @default.
- W2904505884 creator A5043751383 @default.
- W2904505884 creator A5045316983 @default.
- W2904505884 creator A5046924742 @default.
- W2904505884 creator A5060729286 @default.
- W2904505884 creator A5062714997 @default.
- W2904505884 creator A5075446522 @default.
- W2904505884 creator A5078808528 @default.
- W2904505884 creator A5086569955 @default.
- W2904505884 creator A5089137244 @default.
- W2904505884 creator A5089862734 @default.
- W2904505884 date "2019-04-01" @default.
- W2904505884 modified "2023-10-17" @default.
- W2904505884 title "Topography of 11C-Pittsburgh compound B uptake in Alzheimer’s disease: a voxel-based investigation of cortical and white matter regions" @default.
- W2904505884 cites W1837941181 @default.
- W2904505884 cites W1921673553 @default.
- W2904505884 cites W1930947675 @default.
- W2904505884 cites W1971566856 @default.
- W2904505884 cites W1973526765 @default.
- W2904505884 cites W1982834182 @default.
- W2904505884 cites W1987096559 @default.
- W2904505884 cites W1995719450 @default.
- W2904505884 cites W2001085320 @default.
- W2904505884 cites W2001744004 @default.
- W2904505884 cites W2017554498 @default.
- W2904505884 cites W2046638602 @default.
- W2904505884 cites W2053288220 @default.
- W2904505884 cites W2056647705 @default.
- W2904505884 cites W2057401494 @default.
- W2904505884 cites W2064173428 @default.
- W2904505884 cites W2070432394 @default.
- W2904505884 cites W2075582295 @default.
- W2904505884 cites W2077924486 @default.
- W2904505884 cites W2081164888 @default.
- W2904505884 cites W2087267591 @default.
- W2904505884 cites W2089316130 @default.
- W2904505884 cites W2093274439 @default.
- W2904505884 cites W2103132444 @default.
- W2904505884 cites W2106565313 @default.
- W2904505884 cites W2107283998 @default.
- W2904505884 cites W2115017507 @default.
- W2904505884 cites W2124030567 @default.
- W2904505884 cites W2135367355 @default.
- W2904505884 cites W2135591029 @default.
- W2904505884 cites W2140183446 @default.
- W2904505884 cites W2140348797 @default.
- W2904505884 cites W2144868259 @default.
- W2904505884 cites W2155298532 @default.
- W2904505884 cites W2155575770 @default.
- W2904505884 cites W2156133811 @default.
- W2904505884 cites W2159529587 @default.
- W2904505884 cites W2165206443 @default.
- W2904505884 cites W2166416515 @default.
- W2904505884 cites W2167720733 @default.
- W2904505884 cites W2170709967 @default.
- W2904505884 cites W2307741200 @default.
- W2904505884 cites W2470751764 @default.
- W2904505884 cites W2519672513 @default.
- W2904505884 cites W2529649944 @default.
- W2904505884 cites W2560999412 @default.
- W2904505884 cites W2798054687 @default.
- W2904505884 cites W4230920194 @default.
- W2904505884 cites W4245371422 @default.
- W2904505884 doi "https://doi.org/10.1590/1516-4446-2017-0002" @default.
- W2904505884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6781685" @default.
- W2904505884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30540022" @default.
- W2904505884 hasPublicationYear "2019" @default.
- W2904505884 type Work @default.
- W2904505884 sameAs 2904505884 @default.
- W2904505884 citedByCount "17" @default.
- W2904505884 countsByYear W29045058842019 @default.
- W2904505884 countsByYear W29045058842020 @default.
- W2904505884 countsByYear W29045058842021 @default.
- W2904505884 countsByYear W29045058842022 @default.
- W2904505884 countsByYear W29045058842023 @default.
- W2904505884 crossrefType "journal-article" @default.
- W2904505884 hasAuthorship W2904505884A5007804149 @default.
- W2904505884 hasAuthorship W2904505884A5014555108 @default.
- W2904505884 hasAuthorship W2904505884A5024192961 @default.
- W2904505884 hasAuthorship W2904505884A5043751383 @default.
- W2904505884 hasAuthorship W2904505884A5045316983 @default.
- W2904505884 hasAuthorship W2904505884A5046924742 @default.
- W2904505884 hasAuthorship W2904505884A5060729286 @default.
- W2904505884 hasAuthorship W2904505884A5062714997 @default.
- W2904505884 hasAuthorship W2904505884A5075446522 @default.
- W2904505884 hasAuthorship W2904505884A5078808528 @default.
- W2904505884 hasAuthorship W2904505884A5086569955 @default.
- W2904505884 hasAuthorship W2904505884A5089137244 @default.
- W2904505884 hasAuthorship W2904505884A5089862734 @default.
- W2904505884 hasBestOaLocation W29045058841 @default.
- W2904505884 hasConcept C116580362 @default.
- W2904505884 hasConcept C126838900 @default.
- W2904505884 hasConcept C142724271 @default.
- W2904505884 hasConcept C143409427 @default.