FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904505945> ?p ?o ?g. }

• W2904505945 endingPage "224" @default.
• W2904505945 startingPage "215" @default.
• W2904505945 abstract "Acute myocardial infarction (MI) is still a large source of morbidity and mortality worldwide. Although early reperfusion therapy has been prioritized in the modern era of percutaneous coronary intervention and thrombolysis, attempts at incremental improvements in clinical outcomes by reducing MI size have not been successful so far. Herein, we review the studies that have evaluated immediate-onset antiplatelet therapy as attempts to improve meaningful clinical outcomes in ST-segment elevation MI (STEMI). Unfortunately, many of the adjunctive pharmacotherapies have proven to be disappointing. Recent studies performed in the background of routine oral administration of P2Y 12 adenosine receptor inhibitors, which may take several hours to take full effect, and aspirin have largely shown no improvement in outcomes, despite an earlier onset of antiplatelet activity of the investigative agents. Further progress in improving outcomes during STEMI may depend on exploring therapeutics that modulate the pathophysiology of microvascular damage during ischemia–reperfusion injury, a phenomenon whose effects evolve over hours to days. We speculate that the dynamic nature of the no-reflow phenomenon may be an explanation for these disappointing results with the intravenous antiplatelet agents. We hope that appreciation for what has not worked in this domain may direct future research efforts to focus on novel pathways. Myocardial ischemia and reperfusion injury are very much still a lingering issue. Despite significant improvements in door-to-balloon times, rates of in-hospital mortality for STEMI remain unchanged. Outcomes following successfully reperfused STEMI are likely determined by the initial size of myocardial necrosis (ie, cardiomyocyte death during the period of ongoing ischemia), patency of the infarct-related epicardial coronary artery, possible reperfusion injury, the microvascular no-reflow phenomenon, and adverse remodeling after infarction." @default.
• W2904505945 created "2018-12-22" @default.
• W2904505945 creator A5015839705 @default.
• W2904505945 creator A5016711961 @default.
• W2904505945 creator A5026052438 @default.
• W2904505945 creator A5026578587 @default.
• W2904505945 creator A5062213046 @default.
• W2904505945 creator A5074181234 @default.
• W2904505945 creator A5076961983 @default.
• W2904505945 date "2018-12-18" @default.
• W2904505945 modified "2023-10-16" @default.
• W2904505945 title "Do We Need Potent Intravenous Antiplatelet Inhibition at the Time of Reperfusion During ST-Segment Elevation Myocardial Infarction?" @default.
• W2904505945 cites W1428986176 @default.
• W2904505945 cites W1974655135 @default.
• W2904505945 cites W1984639058 @default.
• W2904505945 cites W1994603936 @default.
• W2904505945 cites W2001688139 @default.
• W2904505945 cites W200979310 @default.
• W2904505945 cites W2012680427 @default.
• W2904505945 cites W2014723851 @default.
• W2904505945 cites W2016463307 @default.
• W2904505945 cites W2043950526 @default.
• W2904505945 cites W2057213084 @default.
• W2904505945 cites W2059215195 @default.
• W2904505945 cites W2064145470 @default.
• W2904505945 cites W2071686230 @default.
• W2904505945 cites W2085413583 @default.
• W2904505945 cites W2089715561 @default.
• W2904505945 cites W2097646648 @default.
• W2904505945 cites W2100947498 @default.
• W2904505945 cites W2107797912 @default.
• W2904505945 cites W2110108344 @default.
• W2904505945 cites W2117677020 @default.
• W2904505945 cites W2121741173 @default.
• W2904505945 cites W2125006453 @default.
• W2904505945 cites W2125043491 @default.
• W2904505945 cites W2130350603 @default.
• W2904505945 cites W2136009429 @default.
• W2904505945 cites W2136228924 @default.
• W2904505945 cites W2140501627 @default.
• W2904505945 cites W2142825093 @default.
• W2904505945 cites W2150655309 @default.
• W2904505945 cites W2156266070 @default.
• W2904505945 cites W2156927593 @default.
• W2904505945 cites W2162700772 @default.
• W2904505945 cites W2163606238 @default.
• W2904505945 cites W2168874562 @default.
• W2904505945 cites W2169387542 @default.
• W2904505945 cites W2170949977 @default.
• W2904505945 cites W2183575542 @default.
• W2904505945 cites W2194372997 @default.
• W2904505945 cites W2317861562 @default.
• W2904505945 cites W2331820709 @default.
• W2904505945 cites W2333133657 @default.
• W2904505945 cites W2338522728 @default.
• W2904505945 cites W2468825798 @default.
• W2904505945 cites W2568050971 @default.
• W2904505945 cites W2586072345 @default.
• W2904505945 cites W2741900278 @default.
• W2904505945 cites W2744105079 @default.
• W2904505945 cites W2746779649 @default.
• W2904505945 cites W2749380187 @default.
• W2904505945 cites W2752033985 @default.
• W2904505945 cites W2754054868 @default.
• W2904505945 cites W2795173862 @default.
• W2904505945 cites W2887450556 @default.
• W2904505945 cites W4293372203 @default.
• W2904505945 cites W93049803 @default.
• W2904505945 doi "https://doi.org/10.1177/1074248418812167" @default.
• W2904505945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30563349" @default.
• W2904505945 hasPublicationYear "2018" @default.
• W2904505945 type Work @default.
• W2904505945 sameAs 2904505945 @default.
• W2904505945 citedByCount "9" @default.
• W2904505945 countsByYear W29045059452019 @default.
• W2904505945 countsByYear W29045059452020 @default.
• W2904505945 countsByYear W29045059452021 @default.
• W2904505945 countsByYear W29045059452022 @default.
• W2904505945 countsByYear W29045059452023 @default.
• W2904505945 crossrefType "journal-article" @default.
• W2904505945 hasAuthorship W2904505945A5015839705 @default.
• W2904505945 hasAuthorship W2904505945A5016711961 @default.
• W2904505945 hasAuthorship W2904505945A5026052438 @default.
• W2904505945 hasAuthorship W2904505945A5026578587 @default.
• W2904505945 hasAuthorship W2904505945A5062213046 @default.
• W2904505945 hasAuthorship W2904505945A5074181234 @default.
• W2904505945 hasAuthorship W2904505945A5076961983 @default.
• W2904505945 hasConcept C126322002 @default.
• W2904505945 hasConcept C164705383 @default.
• W2904505945 hasConcept C177713679 @default.
• W2904505945 hasConcept C2775992611 @default.
• W2904505945 hasConcept C2777628954 @default.
• W2904505945 hasConcept C2778300992 @default.
• W2904505945 hasConcept C2779581417 @default.
• W2904505945 hasConcept C2780387585 @default.
• W2904505945 hasConcept C2780400711 @default.
• W2904505945 hasConcept C500558357 @default.
• W2904505945 hasConcept C541997718 @default.

• next