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- W2904509981 abstract "Salmonella spp. are an important cause of foodborne illness in North America, and pork products are associated with sporadic cases and outbreaks of human salmonellosis. Isolates of Salmonella may be resistant to multiple antibiotics, and infections with multidrug-resistant (MDR) Salmonella spp. are more difficult to treat, leading to increased hospitalization rates. Swine operations commonly use antimicrobials, such as chlortetracycline, to prevent/treat infections, which may have collateral effects on pig microbial populations. Recently, we demonstrated that chlortetracycline induces the expression of genes associated with pathogenesis and invasion in MDR Salmonella enterica serovar Typhimurium in vitro . In our current study, we show increased tonsillar colonization and fecal shedding of the MDR S . Typhimurium strain DT104 from pigs administered chlortetracycline. Therefore, pigs unknowingly colonized with multidrug-resistant Salmonella spp. and receiving chlortetracycline for an unrelated infection may be at a greater risk for disseminating MDR Salmonella spp. to other pigs and to humans through environmental or pork product contamination." @default.
- W2904509981 created "2018-12-22" @default.
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- W2904509981 date "2019-02-15" @default.
- W2904509981 modified "2023-09-26" @default.
- W2904509981 title "Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant <i>Salmonella enterica</i> Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota" @default.
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- W2904509981 doi "https://doi.org/10.1128/aem.02354-18" @default.
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