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- W2904554174 abstract "Herein, we describe a one-step synthesis of pharmaceutically relevant 3-(trifluoromethyl)benzofurans from readily accessible 2-alkynylphenols. The method utilizes a domino cyclization/trifluoromethylation strategy with [CuCF3] as a reagent. The CF3 source is the low-cost industrial byproduct fluoroform (CF3H). The assays for antifungal and antibacterial activities conducted on these fluorinated benzofuran derivatives revealed that all were devoid of hemolytic activity toward rabbit erythrocytes indicating absence of toxicity. One of the compounds, 2 g, containing a 4-NH2C6H4 moiety at the C-2 position of the benzofuran core, demonstrated suppressive activity against the fungal pathogens Candida albicans, C. glabrata, and the bacterium methicillin-resistant Staphylococcus aureus, showing minimal inhibitory concentrations (MICs) of 64 μM, 128 μM, and 128 μM, respectively. Incubation of Candida cells with 2 g elicited a time-dependent accumulation of reactive oxygen species (ROS)." @default.
- W2904554174 created "2018-12-22" @default.
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- W2904554174 date "2018-12-19" @default.
- W2904554174 modified "2023-10-16" @default.
- W2904554174 title "Domino Cyclization/Trifluoromethylation of 2‐Alknylphenols for the Synthesis of 3‐(Trifluoromethyl)benzofurans and Evaluation of their Antibacterial and Antifungal Activities" @default.
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- W2904554174 doi "https://doi.org/10.1002/ajoc.201800651" @default.
- W2904554174 hasPublicationYear "2018" @default.
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