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- W2904571704 endingPage "1484" @default.
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- W2904571704 abstract "Abstract In the last decade, cancer immunotherapy has emerged as an effective alternative to traditional therapies such as chemotherapy and radiation. In contrast to the latter, cancer immunotherapy has the potential to distinguish between cancer and healthy cells, and thus to avoid severe and intolerable side‐effects, since the cancer cells are effectively eliminated by stimulated immune cells. The cytosolic nucleotide‐binding oligomerization domains 1 and 2 receptors (NOD1 and NOD2) are important components of the innate immune system and constitute interesting targets in terms of strengthening the immune response against cancer cells. Many NOD ligands have been synthesized, in particular NOD2 agonists that exhibit favorable immunostimulatory and anticancer activity. Among them, mifamurtide has already been approved in Europe by the European Medicine Agency for treating patients with osteosarcoma in combination with chemotherapy after complete surgical removal of the primary tumor. This review is focused on NOD receptors as promising targets in cancer immunotherapy as well as summarizing current knowledge of the various NOD ligands exhibiting antitumor and even antimetastatic activity in vitro and in vivo." @default.
- W2904571704 created "2018-12-22" @default.
- W2904571704 creator A5013630477 @default.
- W2904571704 creator A5028531376 @default.
- W2904571704 creator A5081865434 @default.
- W2904571704 date "2018-12-13" @default.
- W2904571704 modified "2023-09-26" @default.
- W2904571704 title "Harnessing the untapped potential of nucleotide‐binding oligomerization domain ligands for cancer immunotherapy" @default.
- W2904571704 cites W1487474842 @default.
- W2904571704 cites W1514224413 @default.
- W2904571704 cites W1542410645 @default.
- W2904571704 cites W1600472471 @default.
- W2904571704 cites W1606877474 @default.
- W2904571704 cites W1670573097 @default.
- W2904571704 cites W1823137901 @default.
- W2904571704 cites W1843355170 @default.
- W2904571704 cites W1853090251 @default.
- W2904571704 cites W1861728615 @default.
- W2904571704 cites W1964103083 @default.
- W2904571704 cites W1964351040 @default.
- W2904571704 cites W1964564274 @default.
- W2904571704 cites W1965786546 @default.
- W2904571704 cites W1967412346 @default.
- W2904571704 cites W1967890713 @default.
- W2904571704 cites W1971046821 @default.
- W2904571704 cites W1971915082 @default.
- W2904571704 cites W1972645864 @default.
- W2904571704 cites W1972825083 @default.
- W2904571704 cites W1974886333 @default.
- W2904571704 cites W1975026318 @default.
- W2904571704 cites W1976606694 @default.
- W2904571704 cites W1976644844 @default.
- W2904571704 cites W1979736739 @default.
- W2904571704 cites W1983074899 @default.
- W2904571704 cites W1983422325 @default.
- W2904571704 cites W1984607875 @default.
- W2904571704 cites W1985284776 @default.
- W2904571704 cites W1987508836 @default.
- W2904571704 cites W1988428156 @default.
- W2904571704 cites W1989561976 @default.
- W2904571704 cites W1990955264 @default.
- W2904571704 cites W1991117870 @default.
- W2904571704 cites W1991365889 @default.
- W2904571704 cites W1991504481 @default.
- W2904571704 cites W1991819500 @default.
- W2904571704 cites W1991982546 @default.
- W2904571704 cites W1992222025 @default.
- W2904571704 cites W1992618744 @default.
- W2904571704 cites W1994485725 @default.
- W2904571704 cites W1995321760 @default.
- W2904571704 cites W1998903528 @default.
- W2904571704 cites W2000992025 @default.
- W2904571704 cites W2000999642 @default.
- W2904571704 cites W2001166572 @default.
- W2904571704 cites W2001291822 @default.
- W2904571704 cites W2001932393 @default.
- W2904571704 cites W2002011994 @default.
- W2904571704 cites W2003372964 @default.
- W2904571704 cites W2006278240 @default.
- W2904571704 cites W2008025218 @default.
- W2904571704 cites W2008630287 @default.
- W2904571704 cites W2009755744 @default.
- W2904571704 cites W2010551002 @default.
- W2904571704 cites W2012272570 @default.
- W2904571704 cites W2013329696 @default.
- W2904571704 cites W2015934540 @default.
- W2904571704 cites W2018522122 @default.
- W2904571704 cites W2020544908 @default.
- W2904571704 cites W2021490026 @default.
- W2904571704 cites W2021701569 @default.
- W2904571704 cites W2022236896 @default.
- W2904571704 cites W2025970414 @default.
- W2904571704 cites W2027075562 @default.
- W2904571704 cites W2030000698 @default.
- W2904571704 cites W2033622801 @default.
- W2904571704 cites W2033882650 @default.
- W2904571704 cites W2034598207 @default.
- W2904571704 cites W2034715743 @default.
- W2904571704 cites W2036688919 @default.
- W2904571704 cites W2039974717 @default.
- W2904571704 cites W2040024879 @default.
- W2904571704 cites W2041075828 @default.
- W2904571704 cites W2042328552 @default.
- W2904571704 cites W2042675697 @default.
- W2904571704 cites W2043451207 @default.
- W2904571704 cites W2043775908 @default.
- W2904571704 cites W2045743590 @default.
- W2904571704 cites W2046183054 @default.
- W2904571704 cites W2046413950 @default.
- W2904571704 cites W2046705695 @default.
- W2904571704 cites W2047184114 @default.
- W2904571704 cites W2050625644 @default.
- W2904571704 cites W2054098785 @default.
- W2904571704 cites W2054477574 @default.
- W2904571704 cites W2055514614 @default.
- W2904571704 cites W2055926392 @default.
- W2904571704 cites W2056249595 @default.
- W2904571704 cites W2056597496 @default.