FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904586103> ?p ?o ?g. }

• W2904586103 endingPage "3909" @default.
• W2904586103 startingPage "3897" @default.
• W2904586103 abstract "Prolonged culture of metaphase II oocytes is an in vitro aging process that compromises oocyte quality. We tested whether melatonin preserves epigenetic modifications in oocytes after prolonged culture. The porcine oocytes were maturated in vitro for 44 h, and then metaphase II oocytes were continuously cultured in medium supplemented with or without melatonin for 24 h. We found that the parthenogenetic blastocyst formation rate of prolonged-culture oocytes was lower than in fresh oocytes. We further observed that methylation at H3K4me2 and H3K27me2 of oocytes enhanced after prolonged culture. However, 5mc fluorescence intensity was lower in prolonged-culture oocytes than in fresh oocytes. Moreover, the promoter of the imprinted gene NNAT exhibited a higher level of DNA methylation in prolonged-culture oocytes than in fresh oocytes, which was associated with a reduced expression level and glucose uptake capability. Conversely, melatonin improved blastocyst formation rate and preserved histone and DNA methylation modifications, as well as NNAT function in the oocytes after prolonged culture. Notably, DNA methyltransferase inhibitor 5-aza significantly attenuated the protective role of melatonin on genomic DNA methylation. In summary, our results revealed that epigenetic modifications are disrupted in oocytes after prolonged culture, but the changes are reversed by melatonin." @default.
• W2904586103 created "2018-12-22" @default.
• W2904586103 creator A5021532810 @default.
• W2904586103 creator A5044191015 @default.
• W2904586103 creator A5071853417 @default.
• W2904586103 creator A5074231575 @default.
• W2904586103 creator A5082130351 @default.
• W2904586103 creator A5087044141 @default.
• W2904586103 creator A5087372541 @default.
• W2904586103 creator A5088860415 @default.
• W2904586103 date "2018-12-10" @default.
• W2904586103 modified "2023-09-30" @default.
• W2904586103 title "Melatonin prevents deterioration in quality by preserving epigenetic modifications of porcine oocytes after prolonged culture" @default.
• W2904586103 cites W1731932233 @default.
• W2904586103 cites W1974407486 @default.
• W2904586103 cites W1988606322 @default.
• W2904586103 cites W1990785151 @default.
• W2904586103 cites W1996933050 @default.
• W2904586103 cites W2003382270 @default.
• W2904586103 cites W2015497994 @default.
• W2904586103 cites W2020498915 @default.
• W2904586103 cites W2021647295 @default.
• W2904586103 cites W2031586320 @default.
• W2904586103 cites W2049453065 @default.
• W2904586103 cites W2095861132 @default.
• W2904586103 cites W2099022532 @default.
• W2904586103 cites W2106245751 @default.
• W2904586103 cites W2110074893 @default.
• W2904586103 cites W2112483290 @default.
• W2904586103 cites W2113487949 @default.
• W2904586103 cites W2125620255 @default.
• W2904586103 cites W2138090888 @default.
• W2904586103 cites W2160801231 @default.
• W2904586103 cites W2165828372 @default.
• W2904586103 cites W2302044362 @default.
• W2904586103 cites W2302170510 @default.
• W2904586103 cites W2519280707 @default.
• W2904586103 cites W2521145508 @default.
• W2904586103 cites W2529014695 @default.
• W2904586103 cites W2532365768 @default.
• W2904586103 cites W2539736536 @default.
• W2904586103 cites W2582654807 @default.
• W2904586103 cites W2593681724 @default.
• W2904586103 cites W2604032389 @default.
• W2904586103 cites W2668608471 @default.
• W2904586103 cites W2739803291 @default.
• W2904586103 cites W2740963575 @default.
• W2904586103 cites W2767814516 @default.
• W2904586103 cites W2782822491 @default.
• W2904586103 cites W2790509399 @default.
• W2904586103 cites W2790592481 @default.
• W2904586103 cites W2793080681 @default.
• W2904586103 cites W2801875925 @default.
• W2904586103 cites W2884268816 @default.
• W2904586103 cites W2885061080 @default.
• W2904586103 cites W843510236 @default.
• W2904586103 doi "https://doi.org/10.18632/aging.101680" @default.
• W2904586103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6326688" @default.
• W2904586103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30530915" @default.
• W2904586103 hasPublicationYear "2018" @default.
• W2904586103 type Work @default.
• W2904586103 sameAs 2904586103 @default.
• W2904586103 citedByCount "23" @default.
• W2904586103 countsByYear W29045861032019 @default.
• W2904586103 countsByYear W29045861032020 @default.
• W2904586103 countsByYear W29045861032021 @default.
• W2904586103 countsByYear W29045861032022 @default.
• W2904586103 countsByYear W29045861032023 @default.
• W2904586103 crossrefType "journal-article" @default.
• W2904586103 hasAuthorship W2904586103A5021532810 @default.
• W2904586103 hasAuthorship W2904586103A5044191015 @default.
• W2904586103 hasAuthorship W2904586103A5071853417 @default.
• W2904586103 hasAuthorship W2904586103A5074231575 @default.
• W2904586103 hasAuthorship W2904586103A5082130351 @default.
• W2904586103 hasAuthorship W2904586103A5087044141 @default.
• W2904586103 hasAuthorship W2904586103A5087372541 @default.
• W2904586103 hasAuthorship W2904586103A5088860415 @default.
• W2904586103 hasBestOaLocation W29045861031 @default.
• W2904586103 hasConcept C104317684 @default.
• W2904586103 hasConcept C134018914 @default.
• W2904586103 hasConcept C150194340 @default.
• W2904586103 hasConcept C153911025 @default.
• W2904586103 hasConcept C16685009 @default.
• W2904586103 hasConcept C190727270 @default.
• W2904586103 hasConcept C196843134 @default.
• W2904586103 hasConcept C2775966511 @default.
• W2904586103 hasConcept C2776690073 @default.
• W2904586103 hasConcept C2778177303 @default.
• W2904586103 hasConcept C2778182776 @default.
• W2904586103 hasConcept C2779979206 @default.
• W2904586103 hasConcept C33288867 @default.
• W2904586103 hasConcept C41091548 @default.
• W2904586103 hasConcept C54355233 @default.
• W2904586103 hasConcept C552990157 @default.
• W2904586103 hasConcept C71924100 @default.
• W2904586103 hasConcept C86803240 @default.
• W2904586103 hasConcept C87073359 @default.
• W2904586103 hasConcept C91965660 @default.

• next