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- W2904593920 abstract "While there is a controversy regarding the causal relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD), recent studies have demonstrated that the cholesterol efflux capacity (CEC) of HDL is associated with the incidence of CVD. However, there are several limitations to current assays of CEC. First, CEC measurements are not instantly applicable in clinical settings, because CEC assay methods require radiolabeled cholesterol and cultured cells, and these procedures are time consuming. Second, techniques to measure CEC are not standardized. Third, the condition of endogenous cholesterol donors would not be accounted for in the CEC assays. Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as cholesterol uptake capacity (CUC). We demonstrated that CUC represents a residual cardiovascular risk in patients with optimal low-density lipoprotein cholesterol control independently of traditional risk factors, including HDL-C. Establishing reproducible approaches for the cholesterol removal capacity of HDL is required to validate the impact of dysfunctional HDL on cardiovascular risk stratification in the real world." @default.
- W2904593920 created "2018-12-22" @default.
- W2904593920 creator A5087872679 @default.
- W2904593920 date "2019-02-01" @default.
- W2904593920 modified "2023-10-17" @default.
- W2904593920 title "Assessment of HDL Cholesterol Removal Capacity: Toward Clinical Application" @default.
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- W2904593920 doi "https://doi.org/10.5551/jat.rv17028" @default.
- W2904593920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6365149" @default.
- W2904593920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30542002" @default.
- W2904593920 hasPublicationYear "2019" @default.
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