Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904602022> ?p ?o ?g. }
- W2904602022 endingPage "200" @default.
- W2904602022 startingPage "195" @default.
- W2904602022 abstract "Background Optimization of chemotherapy regimens in the treatment of multiple myeloma (MM) has led to increase the frequency of cases with complete response (CR). Nonetheless, many MM patients still experience relapse, suggesting that CR represents a suboptimal response criteria, and that new therapeutic strategies are needed after single transplant. However, the role of double autologous stem cell transplant (ASCT) as new adjunctive strategy remains to be elucidated. Indeed, we investigated the role of minimal residual disease (MRD) and log‐reduction of plasma cells (PCs) as predictors of outcome and in quantifying the degree of tumor reduction after any ASCT. Methods MRD and log‐reduction were assessed by a six‐color flow cytometry (FC) at different time‐points: post induction, post first‐, and post‐second ASCT. Results A significant difference was evidenced among the three time points for both log‐reduction ( P < 0.001) and MRD ( P = 0.005). MRD levels after double ASCT were lower than MRD levels achieved after single ASCT ( P = 0.005) and after induction ( P < 0.001). Frequency of MRD positive patients after double ASCT was significantly lower rather than after the first ASCT ( P = 0.008) and after induction ( P = 0.004). Interestingly, a significant reduction of PFS was observed in patients with an unfavorable‐risk cytogenetic ( P < 0.001) and patients with MRD over 0.01% ( P = 0.001) as well as log‐reduction lower than 2.57 ( P = 0.018) after double ASCT. Conclusions Our results show that a better clearance of myeloma cells is observed after the double ASCT, and a longer PFS is associated with a lower MRD. © 2018 International Clinical Cytometry Society" @default.
- W2904602022 created "2018-12-22" @default.
- W2904602022 creator A5004517658 @default.
- W2904602022 creator A5013475616 @default.
- W2904602022 creator A5020340404 @default.
- W2904602022 creator A5021802241 @default.
- W2904602022 creator A5024136410 @default.
- W2904602022 creator A5030795518 @default.
- W2904602022 creator A5034516887 @default.
- W2904602022 creator A5035335560 @default.
- W2904602022 creator A5084346742 @default.
- W2904602022 creator A5085463818 @default.
- W2904602022 creator A5091664535 @default.
- W2904602022 creator A5091769198 @default.
- W2904602022 date "2018-12-13" @default.
- W2904602022 modified "2023-10-02" @default.
- W2904602022 title "Minimal residual disease and log‐reduction of plasma cells are associated with superior response after double autologous stem cell transplant in younger patients with multiple myeloma" @default.
- W2904602022 cites W1563130519 @default.
- W2904602022 cites W1918445149 @default.
- W2904602022 cites W1963560969 @default.
- W2904602022 cites W1972960382 @default.
- W2904602022 cites W1985021407 @default.
- W2904602022 cites W1990372450 @default.
- W2904602022 cites W2004351861 @default.
- W2904602022 cites W2011871138 @default.
- W2904602022 cites W2020298011 @default.
- W2904602022 cites W2025900814 @default.
- W2904602022 cites W2028286166 @default.
- W2904602022 cites W2090310344 @default.
- W2904602022 cites W2102591890 @default.
- W2904602022 cites W2107057207 @default.
- W2904602022 cites W2108485762 @default.
- W2904602022 cites W2122561221 @default.
- W2904602022 cites W2128084036 @default.
- W2904602022 cites W2136256331 @default.
- W2904602022 cites W2139026714 @default.
- W2904602022 cites W2139260559 @default.
- W2904602022 cites W2148758597 @default.
- W2904602022 cites W2159519833 @default.
- W2904602022 cites W2168812273 @default.
- W2904602022 cites W2297531503 @default.
- W2904602022 cites W2486629951 @default.
- W2904602022 cites W2596637548 @default.
- W2904602022 cites W4236730981 @default.
- W2904602022 cites W4376542883 @default.
- W2904602022 doi "https://doi.org/10.1002/cyto.b.21755" @default.
- W2904602022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30549231" @default.
- W2904602022 hasPublicationYear "2018" @default.
- W2904602022 type Work @default.
- W2904602022 sameAs 2904602022 @default.
- W2904602022 citedByCount "10" @default.
- W2904602022 countsByYear W29046020222019 @default.
- W2904602022 countsByYear W29046020222020 @default.
- W2904602022 countsByYear W29046020222021 @default.
- W2904602022 countsByYear W29046020222022 @default.
- W2904602022 countsByYear W29046020222023 @default.
- W2904602022 crossrefType "journal-article" @default.
- W2904602022 hasAuthorship W2904602022A5004517658 @default.
- W2904602022 hasAuthorship W2904602022A5013475616 @default.
- W2904602022 hasAuthorship W2904602022A5020340404 @default.
- W2904602022 hasAuthorship W2904602022A5021802241 @default.
- W2904602022 hasAuthorship W2904602022A5024136410 @default.
- W2904602022 hasAuthorship W2904602022A5030795518 @default.
- W2904602022 hasAuthorship W2904602022A5034516887 @default.
- W2904602022 hasAuthorship W2904602022A5035335560 @default.
- W2904602022 hasAuthorship W2904602022A5084346742 @default.
- W2904602022 hasAuthorship W2904602022A5085463818 @default.
- W2904602022 hasAuthorship W2904602022A5091664535 @default.
- W2904602022 hasAuthorship W2904602022A5091769198 @default.
- W2904602022 hasBestOaLocation W29046020221 @default.
- W2904602022 hasConcept C126322002 @default.
- W2904602022 hasConcept C126894567 @default.
- W2904602022 hasConcept C143998085 @default.
- W2904602022 hasConcept C203014093 @default.
- W2904602022 hasConcept C2776364478 @default.
- W2904602022 hasConcept C2779050716 @default.
- W2904602022 hasConcept C2779823535 @default.
- W2904602022 hasConcept C2780007613 @default.
- W2904602022 hasConcept C28328180 @default.
- W2904602022 hasConcept C3019389975 @default.
- W2904602022 hasConcept C31903555 @default.
- W2904602022 hasConcept C54355233 @default.
- W2904602022 hasConcept C553184892 @default.
- W2904602022 hasConcept C71924100 @default.
- W2904602022 hasConcept C86803240 @default.
- W2904602022 hasConcept C90924648 @default.
- W2904602022 hasConceptScore W2904602022C126322002 @default.
- W2904602022 hasConceptScore W2904602022C126894567 @default.
- W2904602022 hasConceptScore W2904602022C143998085 @default.
- W2904602022 hasConceptScore W2904602022C203014093 @default.
- W2904602022 hasConceptScore W2904602022C2776364478 @default.
- W2904602022 hasConceptScore W2904602022C2779050716 @default.
- W2904602022 hasConceptScore W2904602022C2779823535 @default.
- W2904602022 hasConceptScore W2904602022C2780007613 @default.
- W2904602022 hasConceptScore W2904602022C28328180 @default.
- W2904602022 hasConceptScore W2904602022C3019389975 @default.
- W2904602022 hasConceptScore W2904602022C31903555 @default.
- W2904602022 hasConceptScore W2904602022C54355233 @default.