FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904602313> ?p ?o ?g. }

• W2904602313 endingPage "338" @default.
• W2904602313 startingPage "315" @default.
• W2904602313 abstract "The GMO90+ project was designed to identify biomarkers of exposure or health effects in Wistar Han RCC rats exposed in their diet to 2 genetically modified plants (GMP) and assess additional information with the use of metabolomic and transcriptomic techniques. Rats were fed for 6-months with 8 maize-based diets at 33% that comprised either MON810 (11% and 33%) or NK603 grains (11% and 33% with or without glyphosate treatment) or their corresponding near-isogenic controls. Extensive chemical and targeted analyses undertaken to assess each diet demonstrated that they could be used for the feeding trial. Rats were necropsied after 3 and 6 months. Based on the Organization for Economic Cooperation and Development test guideline 408, the parameters tested showed a limited number of significant differences in pairwise comparisons, very few concerning GMP versus non-GMP. In such cases, no biological relevance could be established owing to the absence of difference in biologically linked variables, dose-response effects, or clinical disorders. No alteration of the reproduction function and kidney physiology was found. Metabolomics analyses on fluids (blood, urine) were performed after 3, 4.5, and 6 months. Transcriptomics analyses on organs (liver, kidney) were performed after 3 and 6 months. Again, among the significant differences in pairwise comparisons, no GMP effect was observed in contrast to that of maize variety and culture site. Indeed, based on transcriptomic and metabolomic data, we could differentiate MON- to NK-based diets. In conclusion, using this experimental design, no biomarkers of adverse health effect could be attributed to the consumption of GMP diets in comparison with the consumption of their near-isogenic non-GMP controls." @default.
• W2904602313 created "2018-12-22" @default.
• W2904602313 creator A5000394997 @default.
• W2904602313 creator A5001813148 @default.
• W2904602313 creator A5007829453 @default.
• W2904602313 creator A5008703920 @default.
• W2904602313 creator A5010350182 @default.
• W2904602313 creator A5010518060 @default.
• W2904602313 creator A5012884320 @default.
• W2904602313 creator A5013753442 @default.
• W2904602313 creator A5020257925 @default.
• W2904602313 creator A5020986858 @default.
• W2904602313 creator A5023726441 @default.
• W2904602313 creator A5025860906 @default.
• W2904602313 creator A5048137300 @default.
• W2904602313 creator A5049343245 @default.
• W2904602313 creator A5053877774 @default.
• W2904602313 creator A5057554178 @default.
• W2904602313 creator A5058260355 @default.
• W2904602313 creator A5058781334 @default.
• W2904602313 creator A5059903212 @default.
• W2904602313 creator A5059915717 @default.
• W2904602313 creator A5060935400 @default.
• W2904602313 creator A5063201864 @default.
• W2904602313 creator A5066694937 @default.
• W2904602313 creator A5068757506 @default.
• W2904602313 creator A5069880922 @default.
• W2904602313 creator A5072219849 @default.
• W2904602313 creator A5073561748 @default.
• W2904602313 creator A5075813736 @default.
• W2904602313 creator A5077962900 @default.
• W2904602313 creator A5081184541 @default.
• W2904602313 creator A5081497064 @default.
• W2904602313 creator A5082161589 @default.
• W2904602313 date "2018-12-10" @default.
• W2904602313 modified "2023-10-18" @default.
• W2904602313 title "The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial" @default.
• W2904602313 cites W1532063136 @default.
• W2904602313 cites W1966829335 @default.
• W2904602313 cites W1969985548 @default.
• W2904602313 cites W1972944772 @default.
• W2904602313 cites W1974782561 @default.
• W2904602313 cites W1984056103 @default.
• W2904602313 cites W1990651190 @default.
• W2904602313 cites W2003362676 @default.
• W2904602313 cites W2012910743 @default.
• W2904602313 cites W2020848465 @default.
• W2904602313 cites W2023535481 @default.
• W2904602313 cites W2048837612 @default.
• W2904602313 cites W2056972503 @default.
• W2904602313 cites W2066269932 @default.
• W2904602313 cites W2079775628 @default.
• W2904602313 cites W2081098333 @default.
• W2904602313 cites W2082246284 @default.
• W2904602313 cites W2087914320 @default.
• W2904602313 cites W2102843125 @default.
• W2904602313 cites W2103188354 @default.
• W2904602313 cites W2120865735 @default.
• W2904602313 cites W2123182718 @default.
• W2904602313 cites W2125541785 @default.
• W2904602313 cites W2128203876 @default.
• W2904602313 cites W2141643126 @default.
• W2904602313 cites W2143746117 @default.
• W2904602313 cites W2149027575 @default.
• W2904602313 cites W2152135658 @default.
• W2904602313 cites W2160697532 @default.
• W2904602313 cites W2165577915 @default.
• W2904602313 cites W2165583710 @default.
• W2904602313 cites W2184368797 @default.
• W2904602313 cites W2472786154 @default.
• W2904602313 cites W2504930139 @default.
• W2904602313 cites W2531936635 @default.
• W2904602313 cites W2586501010 @default.
• W2904602313 cites W2605415580 @default.
• W2904602313 cites W2777037074 @default.
• W2904602313 cites W2789252708 @default.
• W2904602313 cites W2892745577 @default.
• W2904602313 cites W2916279557 @default.
• W2904602313 cites W2917078679 @default.
• W2904602313 cites W4214757067 @default.
• W2904602313 cites W4235406197 @default.
• W2904602313 cites W4236571741 @default.
• W2904602313 cites W4361744942 @default.
• W2904602313 doi "https://doi.org/10.1093/toxsci/kfy298" @default.
• W2904602313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6432862" @default.
• W2904602313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30535037" @default.
• W2904602313 hasPublicationYear "2018" @default.
• W2904602313 type Work @default.
• W2904602313 sameAs 2904602313 @default.
• W2904602313 citedByCount "12" @default.
• W2904602313 countsByYear W29046023132019 @default.
• W2904602313 countsByYear W29046023132020 @default.
• W2904602313 countsByYear W29046023132021 @default.
• W2904602313 countsByYear W29046023132022 @default.
• W2904602313 countsByYear W29046023132023 @default.
• W2904602313 crossrefType "journal-article" @default.
• W2904602313 hasAuthorship W2904602313A5000394997 @default.
• W2904602313 hasAuthorship W2904602313A5001813148 @default.

• next