FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904602873> ?p ?o ?g. }

• W2904602873 endingPage "39" @default.
• W2904602873 startingPage "34" @default.
• W2904602873 abstract "Circulating tumor cells (CTCs) are cells that have shed from tumor tissue into the bloodstream, and the detection and characterization of CTCs in head and neck squamous cell carcinoma (HNSCC) still remain a challenge.CTCs were isolated from 30 patients with HNSCC with recurrent and/or distant metastasis, via the depletion of CD45-positive cells with magnetic beads and the expression of multiple epithelial markers (CK19, EpCAM, EGFR, and c-Met) was analyzed by RT-qPCR with a low concentration of RNA from the CTC population. We next investigated the expression of the immune-regulatory molecules, PD-L1, PD-L2, and CD47, in CTC-positive patients and the PD-L1 expression in CTCs was compared with that in tumor tissues.Twenty-four (80.0%) of the 30 patients were positive for at least one epithelial-related gene. Among the 24 CTC-positive patients, 19 (79.2%), 20 (83.3%), and 17 (70.8%) patients were positive for CD47, PD-L1, and PD-L2, respectively. Interestingly, the expression of these three immune-regulatory molecules was positively correlated to each other. As expected, PD-L1 expression in the tumor tissue did not correspond completely with that in the CTCs.Although clinical application and/or characterization of CTCs are still developing, our findings suggest that the CTCs are rapidly becoming a powerful tool in cancer treatments that involve the use of immune checkpoint inhibitors." @default.
• W2904602873 created "2018-12-22" @default.
• W2904602873 creator A5000424496 @default.
• W2904602873 creator A5017555489 @default.
• W2904602873 creator A5034664491 @default.
• W2904602873 creator A5047832933 @default.
• W2904602873 creator A5053418699 @default.
• W2904602873 creator A5056081259 @default.
• W2904602873 creator A5074929594 @default.
• W2904602873 date "2019-02-01" @default.
• W2904602873 modified "2023-09-29" @default.
• W2904602873 title "Expression of immune-regulatory molecules in circulating tumor cells derived from patients with head and neck squamous cell carcinoma" @default.
• W2904602873 cites W1947727969 @default.
• W2904602873 cites W1966217032 @default.
• W2904602873 cites W1968464607 @default.
• W2904602873 cites W1968700783 @default.
• W2904602873 cites W2020737703 @default.
• W2904602873 cites W2023832104 @default.
• W2904602873 cites W2057499380 @default.
• W2904602873 cites W2060070314 @default.
• W2904602873 cites W2063211029 @default.
• W2904602873 cites W2087716042 @default.
• W2904602873 cites W2092011367 @default.
• W2904602873 cites W2103164876 @default.
• W2904602873 cites W2107277218 @default.
• W2904602873 cites W2130172613 @default.
• W2904602873 cites W2133346943 @default.
• W2904602873 cites W2157553162 @default.
• W2904602873 cites W2210073947 @default.
• W2904602873 cites W2295526061 @default.
• W2904602873 cites W2339075220 @default.
• W2904602873 cites W2469445173 @default.
• W2904602873 cites W2473212158 @default.
• W2904602873 cites W2556232360 @default.
• W2904602873 cites W2588207942 @default.
• W2904602873 cites W2612431515 @default.
• W2904602873 cites W2614304706 @default.
• W2904602873 cites W2616692187 @default.
• W2904602873 cites W2626459434 @default.
• W2904602873 cites W2626773261 @default.
• W2904602873 cites W2724946178 @default.
• W2904602873 cites W2746311720 @default.
• W2904602873 cites W2762923518 @default.
• W2904602873 cites W2768434280 @default.
• W2904602873 cites W2784174743 @default.
• W2904602873 doi "https://doi.org/10.1016/j.oraloncology.2018.12.002" @default.
• W2904602873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30732956" @default.
• W2904602873 hasPublicationYear "2019" @default.
• W2904602873 type Work @default.
• W2904602873 sameAs 2904602873 @default.
• W2904602873 citedByCount "30" @default.
• W2904602873 countsByYear W29046028732019 @default.
• W2904602873 countsByYear W29046028732020 @default.
• W2904602873 countsByYear W29046028732021 @default.
• W2904602873 countsByYear W29046028732022 @default.
• W2904602873 countsByYear W29046028732023 @default.
• W2904602873 crossrefType "journal-article" @default.
• W2904602873 hasAuthorship W2904602873A5000424496 @default.
• W2904602873 hasAuthorship W2904602873A5017555489 @default.
• W2904602873 hasAuthorship W2904602873A5034664491 @default.
• W2904602873 hasAuthorship W2904602873A5047832933 @default.
• W2904602873 hasAuthorship W2904602873A5053418699 @default.
• W2904602873 hasAuthorship W2904602873A5056081259 @default.
• W2904602873 hasAuthorship W2904602873A5074929594 @default.
• W2904602873 hasConcept C121608353 @default.
• W2904602873 hasConcept C126322002 @default.
• W2904602873 hasConcept C142724271 @default.
• W2904602873 hasConcept C143998085 @default.
• W2904602873 hasConcept C159654299 @default.
• W2904602873 hasConcept C203014093 @default.
• W2904602873 hasConcept C2776530083 @default.
• W2904602873 hasConcept C2776833033 @default.
• W2904602873 hasConcept C2777701055 @default.
• W2904602873 hasConcept C2779013556 @default.
• W2904602873 hasConcept C2781053074 @default.
• W2904602873 hasConcept C2908647359 @default.
• W2904602873 hasConcept C502942594 @default.
• W2904602873 hasConcept C61238886 @default.
• W2904602873 hasConcept C71924100 @default.
• W2904602873 hasConcept C8891405 @default.
• W2904602873 hasConcept C99454951 @default.
• W2904602873 hasConceptScore W2904602873C121608353 @default.
• W2904602873 hasConceptScore W2904602873C126322002 @default.
• W2904602873 hasConceptScore W2904602873C142724271 @default.
• W2904602873 hasConceptScore W2904602873C143998085 @default.
• W2904602873 hasConceptScore W2904602873C159654299 @default.
• W2904602873 hasConceptScore W2904602873C203014093 @default.
• W2904602873 hasConceptScore W2904602873C2776530083 @default.
• W2904602873 hasConceptScore W2904602873C2776833033 @default.
• W2904602873 hasConceptScore W2904602873C2777701055 @default.
• W2904602873 hasConceptScore W2904602873C2779013556 @default.
• W2904602873 hasConceptScore W2904602873C2781053074 @default.
• W2904602873 hasConceptScore W2904602873C2908647359 @default.
• W2904602873 hasConceptScore W2904602873C502942594 @default.
• W2904602873 hasConceptScore W2904602873C61238886 @default.
• W2904602873 hasConceptScore W2904602873C71924100 @default.
• W2904602873 hasConceptScore W2904602873C8891405 @default.
• W2904602873 hasConceptScore W2904602873C99454951 @default.

• next