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- W2904603472 abstract "We investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer's disease (AD) and age-matched non-AD brains and APP/PS1 transgenic model mice.APs and adjacent control regions were collected from fresh-frozen brain sections using laser capture dissection. Proteins were quantitated using tag-labeling coupled high-throughput mass spectra.Over 4000 proteins were accurately quantified, and more than 40 were identified as highly enriched in both AD and non-AD APs, including apoE, midkine, VGFR1, and complement C4. Intriguingly, proteins including synaptic structural proteins and complement C1r, C5, and C9 were found to be upregulated in AD APs but not non-AD APs. Moreover, the proteomic pattern of AD APs was distinct from APP/PS1 APs and exhibited correlation with aging hippocampus.Our results provide new insight into AP composition. We demonstrate unexpected differences between AD, non-AD, and APP/PS1 mouse APs, which may relate to different pathological processes." @default.
- W2904603472 created "2018-12-22" @default.
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- W2904603472 date "2018-11-28" @default.
- W2904603472 modified "2023-10-15" @default.
- W2904603472 title "Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease" @default.
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- W2904603472 doi "https://doi.org/10.1016/j.jalz.2018.10.006" @default.
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