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• W2904608802 abstract "Developing and validating sensitive biomarkers for the presymptomatic stage of familial frontotemporal dementia is an important step in early diagnosis and for the design of future therapeutic trials. In the longitudinal Frontotemporal Dementia Risk Cohort, presymptomatic mutation carriers and non-carriers from families with familial frontotemporal dementia due to microtubule-associated protein tau (MAPT) and progranulin (GRN) mutations underwent a clinical assessment and multimodal MRI at baseline, 2-, and 4-year follow-up. Of the cohort of 73 participants, eight mutation carriers (three GRN, five MAPT) developed clinical features of frontotemporal dementia ('converters'). Longitudinal whole-brain measures of white matter integrity (fractional anisotropy) and grey matter volume in these converters (n = 8) were compared with healthy mutation carriers ('non-converters'; n = 35) and non-carriers (n = 30) from the same families. We also assessed the prognostic performance of decline within white matter and grey matter regions of interest by means of receiver operating characteristic analyses followed by stepwise logistic regression. Longitudinal whole-brain analyses demonstrated lower fractional anisotropy values in extensive white matter regions (genu corpus callosum, forceps minor, uncinate fasciculus, and superior longitudinal fasciculus) and smaller grey matter volumes (prefrontal, temporal, cingulate, and insular cortex) over time in converters, present from 2 years before symptom onset. White matter integrity loss of the right uncinate fasciculus and genu corpus callosum provided significant classifiers between converters, non-converters, and non-carriers. Converters' within-individual disease trajectories showed a relatively gradual onset of clinical features in MAPT, whereas GRN mutations had more rapid changes around symptom onset. MAPT converters showed more decline in the uncinate fasciculus than GRN converters, and more decline in the genu corpus callosum in GRN than MAPT converters. Our study confirms the presence of spreading predominant frontotemporal pathology towards symptom onset and highlights the value of multimodal MRI as a prognostic biomarker in familial frontotemporal dementia." @default.
• W2904608802 created "2018-12-22" @default.
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• W2904608802 date "2018-11-30" @default.
• W2904608802 modified "2023-10-12" @default.
• W2904608802 title "Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia" @default.
• W2904608802 cites W140099315 @default.
• W2904608802 cites W1536749812 @default.
• W2904608802 cites W1586285828 @default.
• W2904608802 cites W1823256591 @default.
• W2904608802 cites W1823618591 @default.
• W2904608802 cites W1847168837 @default.
• W2904608802 cites W1970578687 @default.
• W2904608802 cites W1980827933 @default.
• W2904608802 cites W1981937737 @default.
• W2904608802 cites W1984148891 @default.
• W2904608802 cites W1986452225 @default.
• W2904608802 cites W1995714006 @default.
• W2904608802 cites W2005433395 @default.
• W2904608802 cites W2005487413 @default.
• W2904608802 cites W2008854521 @default.
• W2904608802 cites W2012340448 @default.
• W2904608802 cites W2021422157 @default.
• W2904608802 cites W2026273357 @default.
• W2904608802 cites W2028309433 @default.
• W2904608802 cites W2032929253 @default.
• W2904608802 cites W2034517662 @default.
• W2904608802 cites W2040461025 @default.
• W2904608802 cites W2053288220 @default.
• W2904608802 cites W2053662508 @default.
• W2904608802 cites W2058161128 @default.
• W2904608802 cites W2061056353 @default.
• W2904608802 cites W2067495470 @default.
• W2904608802 cites W2080730920 @default.
• W2904608802 cites W2097764378 @default.
• W2904608802 cites W2099880194 @default.
• W2904608802 cites W2103579962 @default.
• W2904608802 cites W2103717170 @default.
• W2904608802 cites W2105121811 @default.
• W2904608802 cites W2106786486 @default.
• W2904608802 cites W2110388059 @default.
• W2904608802 cites W2113661629 @default.
• W2904608802 cites W2124433209 @default.
• W2904608802 cites W2128030851 @default.
• W2904608802 cites W2129821250 @default.
• W2904608802 cites W2129981926 @default.
• W2904608802 cites W2138190873 @default.
• W2904608802 cites W2144021643 @default.
• W2904608802 cites W2147009297 @default.
• W2904608802 cites W2147948236 @default.
• W2904608802 cites W2148080316 @default.
• W2904608802 cites W2152018727 @default.
• W2904608802 cites W2152575748 @default.
• W2904608802 cites W2154223956 @default.
• W2904608802 cites W2155738222 @default.
• W2904608802 cites W2160776412 @default.
• W2904608802 cites W2161762785 @default.
• W2904608802 cites W2162682998 @default.
• W2904608802 cites W2165754388 @default.
• W2904608802 cites W2167311298 @default.
• W2904608802 cites W2171250577 @default.
• W2904608802 cites W2172054053 @default.
• W2904608802 cites W2262171011 @default.
• W2904608802 cites W2460723165 @default.
• W2904608802 cites W2470439561 @default.
• W2904608802 cites W2474047710 @default.
• W2904608802 cites W2506919437 @default.
• W2904608802 cites W2522532977 @default.
• W2904608802 cites W2537446510 @default.
• W2904608802 cites W2579510648 @default.
• W2904608802 cites W2619097621 @default.
• W2904608802 cites W2619930792 @default.
• W2904608802 cites W2625115119 @default.
• W2904608802 cites W2625796101 @default.
• W2904608802 cites W2737966001 @default.
• W2904608802 cites W2755256217 @default.
• W2904608802 cites W2766970894 @default.
• W2904608802 cites W2779456063 @default.
• W2904608802 cites W2785189257 @default.
• W2904608802 cites W2788086012 @default.
• W2904608802 cites W2795986531 @default.
• W2904608802 cites W2847223726 @default.
• W2904608802 cites W349712691 @default.
• W2904608802 cites W4251162813 @default.
• W2904608802 cites W831936796 @default.
• W2904608802 doi "https://doi.org/10.1093/brain/awy288" @default.
• W2904608802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6308313" @default.
• W2904608802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30508042" @default.

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