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- W2904612013 abstract "The Front Cover shows the concept of library screening with MS binding assays. The libraries are generated by a simple reaction of a building block (Σ) with reactants with complementary reactivity and varying structures (A–X). Upon subsequent incubation with the target mGAT1, library members (ΣA–ΣH, ΣI–ΣP, ΣQ–ΣX) are selected according to their affinity towards the target. Best binders of libraries (ΣA) are identified by monitoring the amount of liberated reporter ligand (Φ) through (ESI)–MS/MS. As demonstrated by the results, MS binding assays represent a powerful tool in library screening. Cover illustration by Dr. Jörg Pabel. More information can be found in the Full Paper by Klaus T. Wanner et al. on page 2488 in Issue 23, 2018 (DOI: 10.1002/cmdc.201800556)." @default.
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- W2904612013 date "2018-12-04" @default.
- W2904612013 modified "2023-10-16" @default.
- W2904612013 title "Front Cover: Identification of Pyrrolidine‐3‐acetic Acid Derived Oximes as Potent Inhibitors of γ‐Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays (ChemMedChem 23/2018)" @default.
- W2904612013 doi "https://doi.org/10.1002/cmdc.201800740" @default.
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