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- W2904612175 abstract "Abstract Visceral pain arising from internal organs is a common clinical symptom of multiple diseases impacting millions of people, yet it is poorly managed. There is evidence that changes in chromatin structure drive stable alterations in gene expression during pain conditions, which underlie several symptoms, including visceral hypersensitivity and anxiety. Epigenetic modulation including DNA methylation, histone modifications, and noncoding RNA regulates visceral pain through enhancing or suppressing receptors of neurotransmitters in the nervous system. Recent findings of epigenetic changes in the peripheral and central nervous system during visceral pain may guide fundamental progress in new treatment targets. In this chapter, we provide a brief overview of still-limited literature that directly implicates epigenetic modifications on visceral pain." @default.
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- W2904612175 date "2019-01-01" @default.
- W2904612175 modified "2023-09-23" @default.
- W2904612175 title "Epigenetic Modulation of Visceral Pain" @default.
- W2904612175 doi "https://doi.org/10.1016/b978-0-12-814070-3.00008-9" @default.
- W2904612175 hasPublicationYear "2019" @default.
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