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• W2904612650 abstract "The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficient sensitivity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were ‘Fish and other seafood’, ‘Meat and meat products’ and ‘Eggs and egg products’, for PFOS, and ‘Milk and dairy products’, ‘Drinking water’ and ‘Fish and other seafood’ for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half-lives for PFOS and PFOA are about 5 years and 2–4 years, respectively. The derivation of a health-based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs." @default.
• W2904612650 created "2018-12-22" @default.
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• W2904612650 date "2018-12-01" @default.
• W2904612650 modified "2023-10-18" @default.
• W2904612650 title "Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food" @default.
• W2904612650 cites W1007495478 @default.
• W2904612650 cites W1079868914 @default.
• W2904612650 cites W1151114854 @default.
• W2904612650 cites W1153825249 @default.
• W2904612650 cites W1268969431 @default.
• W2904612650 cites W1469657290 @default.
• W2904612650 cites W1505273877 @default.
• W2904612650 cites W1512113935 @default.
• W2904612650 cites W1513271034 @default.
• W2904612650 cites W1517876547 @default.
• W2904612650 cites W1519535750 @default.
• W2904612650 cites W1543420482 @default.
• W2904612650 cites W1607804102 @default.
• W2904612650 cites W1693907336 @default.
• W2904612650 cites W1694693019 @default.
• W2904612650 cites W1751780479 @default.
• W2904612650 cites W1765274633 @default.
• W2904612650 cites W1771099042 @default.
• W2904612650 cites W1818356970 @default.
• W2904612650 cites W1855179430 @default.
• W2904612650 cites W1876440262 @default.
• W2904612650 cites W1903558971 @default.
• W2904612650 cites W1914863002 @default.
• W2904612650 cites W1936217412 @default.
• W2904612650 cites W1942309564 @default.
• W2904612650 cites W1951187588 @default.
• W2904612650 cites W1964548922 @default.
• W2904612650 cites W1964562937 @default.
• W2904612650 cites W1965185429 @default.
• W2904612650 cites W1965476640 @default.
• W2904612650 cites W1966078713 @default.
• W2904612650 cites W1966130148 @default.
• W2904612650 cites W1966204155 @default.
• W2904612650 cites W1966209976 @default.
• W2904612650 cites W1967359640 @default.
• W2904612650 cites W1968054662 @default.
• W2904612650 cites W1968106661 @default.
• W2904612650 cites W1968428918 @default.
• W2904612650 cites W1968700347 @default.
• W2904612650 cites W1968866806 @default.
• W2904612650 cites W1968946810 @default.
• W2904612650 cites W1969107063 @default.
• W2904612650 cites W1969817100 @default.
• W2904612650 cites W1969826394 @default.
• W2904612650 cites W1969833991 @default.
• W2904612650 cites W1969835924 @default.
• W2904612650 cites W1970016764 @default.
• W2904612650 cites W1970158294 @default.
• W2904612650 cites W1970222068 @default.
• W2904612650 cites W1970595390 @default.
• W2904612650 cites W1970940769 @default.
• W2904612650 cites W1970990727 @default.
• W2904612650 cites W1971106859 @default.
• W2904612650 cites W1971452458 @default.
• W2904612650 cites W1971495490 @default.
• W2904612650 cites W1972243821 @default.
• W2904612650 cites W1972268723 @default.
• W2904612650 cites W1972550453 @default.
• W2904612650 cites W1972809876 @default.
• W2904612650 cites W1972920930 @default.
• W2904612650 cites W1973514297 @default.
• W2904612650 cites W1973699758 @default.
• W2904612650 cites W1974206202 @default.
• W2904612650 cites W1974264164 @default.

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