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- W2904625712 abstract "Abstract The exponential increase in methylphenidate (MPH) prescriptions in recent years has worried researchers about its misuse among individuals who do not meet the full diagnostic criteria for attention‐deficit/hyperactivity disorder (ADHD) such as young children and students in search of cognitive improvement or for recreational reasons. The action of MPH is based mainly on inhibition of dopamine transporter, but the complete cellular effects are still unknown. Based upon prior studies, we attempted to determine whether the treatment with MPH (1μM) influences protein kinase B‐mammalian target of rapamycin complex 1 signaling pathways (Akt‐mTOR), including translation repressor protein (4E‐BP1) and mitogen activated protein kinase (S6K), in rat pheochromocytoma cells (PC12), a well characterized cellular model, in a long or short term. MPH effects on the Akt substrates [cAMP response element‐binding protein (CREB), forkhead box protein O1 (FoxO1), and glycogen synthase kinase 3 beta (GSK‐3β)] were also evaluated. Whereas short term MPH treatment decreased the pAkt/Akt, pmTOR/mTOR and pS6K/S6K ratios, as well as pFoxO1 immunocontent in PC12 cells, long term treatment increased pAkt/Akt, pmTOR/mTOR and pGSK‐3β/GSK‐3β ratio. Phosphorylation levels of 4E‐BP1 were decreased at 15 and 30 min and increased at 1 and 6 h by MPH. pCREB/CREB ratio was decreased. This study shows that the Akt‐mTOR pathway, as well as other important Akt substrates which have been described as important regulators of protein synthesis, as well as being implicated in cellular survival, synaptic plasticity and memory consolidation, was affected by MPH in PC12 cells, representing an important step in exploring the MPH effects." @default.
- W2904625712 created "2018-12-22" @default.
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- W2904625712 creator A5083842270 @default.
- W2904625712 creator A5084643526 @default.
- W2904625712 date "2018-12-19" @default.
- W2904625712 modified "2023-09-26" @default.
- W2904625712 title "Methylphenidate alters Akt‐mTOR signaling in rat pheochromocytoma cells" @default.
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- W2904625712 doi "https://doi.org/10.1016/j.ijdevneu.2018.12.004" @default.
- W2904625712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30578823" @default.
- W2904625712 hasPublicationYear "2018" @default.
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