Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904641103> ?p ?o ?g. }
- W2904641103 abstract "Complex aging triggered disorders are multifactorial programs that comprise multiple alterations in interconnected protein networks over a large range of tissues. To coordinate the generation of these pathological events, it is evident that rather than being randomly organized pathophysiologies that possess a strong aging component such as cardiovascular diseases (hypertensions, atherosclerosis and vascular stiffening) and neurodegenerative conditions (dementia, Alzheimers disease, mild cognitive impairment, Parkinsons disease), they represent a modified version of the intricate molecular aging programs already in place. To control such multidimensional functions there are layers of trophic protein control across these networks mediated by keystone proteins. These proteins interact and regulate multiple signaling pathways to engender a whole somatic phenotype, here we posit that the G protein coupled receptor kinase 5 (GRK5) represents one of these key controllers. Considerable data has emerged, suggesting that GRK5 acts as a bridging factor, allowing signaling regulation in pathophysiological settings to control both the cardiovascular and neurophysiological complications of aging." @default.
- W2904641103 created "2018-12-22" @default.
- W2904641103 creator A5022772284 @default.
- W2904641103 creator A5033862949 @default.
- W2904641103 creator A5040043212 @default.
- W2904641103 creator A5049597190 @default.
- W2904641103 creator A5054354115 @default.
- W2904641103 creator A5061101747 @default.
- W2904641103 creator A5075080025 @default.
- W2904641103 date "2018-12-17" @default.
- W2904641103 modified "2023-10-07" @default.
- W2904641103 title "GRK5 – A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders" @default.
- W2904641103 cites W111361069 @default.
- W2904641103 cites W119628112 @default.
- W2904641103 cites W1483932465 @default.
- W2904641103 cites W1499511192 @default.
- W2904641103 cites W1502124600 @default.
- W2904641103 cites W1508524753 @default.
- W2904641103 cites W1546091073 @default.
- W2904641103 cites W1550545417 @default.
- W2904641103 cites W1551715961 @default.
- W2904641103 cites W1568927421 @default.
- W2904641103 cites W1616122655 @default.
- W2904641103 cites W1718435705 @default.
- W2904641103 cites W1885101497 @default.
- W2904641103 cites W1921523468 @default.
- W2904641103 cites W1938667969 @default.
- W2904641103 cites W1952293023 @default.
- W2904641103 cites W1963816294 @default.
- W2904641103 cites W1964064254 @default.
- W2904641103 cites W1965608446 @default.
- W2904641103 cites W1966691229 @default.
- W2904641103 cites W1968273731 @default.
- W2904641103 cites W1971454022 @default.
- W2904641103 cites W1972439950 @default.
- W2904641103 cites W1973181970 @default.
- W2904641103 cites W1973258894 @default.
- W2904641103 cites W1974361709 @default.
- W2904641103 cites W1974976404 @default.
- W2904641103 cites W1975211756 @default.
- W2904641103 cites W1976258716 @default.
- W2904641103 cites W1976409750 @default.
- W2904641103 cites W1976774500 @default.
- W2904641103 cites W1978043034 @default.
- W2904641103 cites W1979600161 @default.
- W2904641103 cites W1979793055 @default.
- W2904641103 cites W1980793024 @default.
- W2904641103 cites W1982096684 @default.
- W2904641103 cites W1983255701 @default.
- W2904641103 cites W1983401747 @default.
- W2904641103 cites W1983732891 @default.
- W2904641103 cites W1984101571 @default.
- W2904641103 cites W1984449540 @default.
- W2904641103 cites W1985500587 @default.
- W2904641103 cites W1986370459 @default.
- W2904641103 cites W1986711175 @default.
- W2904641103 cites W1986748474 @default.
- W2904641103 cites W1989067106 @default.
- W2904641103 cites W1992933423 @default.
- W2904641103 cites W1994067502 @default.
- W2904641103 cites W1994141837 @default.
- W2904641103 cites W1995262004 @default.
- W2904641103 cites W1996347377 @default.
- W2904641103 cites W1996480483 @default.
- W2904641103 cites W1997205555 @default.
- W2904641103 cites W1997786976 @default.
- W2904641103 cites W1998046189 @default.
- W2904641103 cites W1998963916 @default.
- W2904641103 cites W2000097800 @default.
- W2904641103 cites W2000147356 @default.
- W2904641103 cites W2000267199 @default.
- W2904641103 cites W2004791695 @default.
- W2904641103 cites W2005723902 @default.
- W2904641103 cites W2006193103 @default.
- W2904641103 cites W2006224306 @default.
- W2904641103 cites W2006268283 @default.
- W2904641103 cites W2007600820 @default.
- W2904641103 cites W2009156962 @default.
- W2904641103 cites W2009358765 @default.
- W2904641103 cites W2010571388 @default.
- W2904641103 cites W2013526015 @default.
- W2904641103 cites W2019330476 @default.
- W2904641103 cites W2021006625 @default.
- W2904641103 cites W2021810024 @default.
- W2904641103 cites W2022576341 @default.
- W2904641103 cites W2022782373 @default.
- W2904641103 cites W2023462189 @default.
- W2904641103 cites W2023503125 @default.
- W2904641103 cites W2024921351 @default.
- W2904641103 cites W2025217136 @default.
- W2904641103 cites W2026363968 @default.
- W2904641103 cites W2026493203 @default.
- W2904641103 cites W2027842111 @default.
- W2904641103 cites W2031711420 @default.
- W2904641103 cites W2031775245 @default.
- W2904641103 cites W2032833505 @default.
- W2904641103 cites W2033187068 @default.
- W2904641103 cites W2033945588 @default.
- W2904641103 cites W2034379667 @default.
- W2904641103 cites W2034426366 @default.