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• W2904642273 abstract "Abstract To investigate the role of ultrasound‐targeted microbubbles in the homing effect of bone marrow‐derived mesenchymal stem cells (BMSCs) and in the therapeutic efficacy of BMSCs on the ischemic stroke. A middle cerebral artery occlusion (MCAO) model was induced by plug wire preparation. Seventy‐two hours after MCAO, the treatment of BMSCs with ultrasound‐targeted microbubble was assessed via modified neurological severity score (mNSS), infarct volumes, and cerebral edema. In addition, immunofluorescence was performed to analyze the homing effect of BMSCs with ultrasound‐targeted microbubble. We find that BMSCs with ultrasound‐targeted microbubble (BMMSCs with ultrasound‐targeted microbubble [USMM] group) could significantly ameliorate mNSS, infarct volumes, and cerebral edema of MCAO compared with phosphate buffer saline group, BMSCs alone group (BMSC group), and BMSCs with Ultrasound group (Ultrasound group). Immunofluorescence analysis demonstrated that ultrasound‐targeted microbubbles promoted the accumulation of BMSCs in rat MCAO brains. Our findings demonstrated that ultrasound‐targeted microbubble could be an effective approach for the accumulation of BMSCs on ischemic stroke, and further improved the therapeutic efficacy of BMSCs on MCAO." @default.
• W2904642273 created "2018-12-22" @default.
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• W2904642273 date "2018-12-09" @default.
• W2904642273 modified "2023-09-27" @default.
• W2904642273 title "Ultrasound‐targeted microbubble enhances migration and therapeutic efficacy of marrow mesenchymal stem cell on rat middle cerebral artery occlusion stroke model" @default.
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• W2904642273 doi "https://doi.org/10.1002/jcb.27600" @default.
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