FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904647658> ?p ?o ?g. }

• W2904647658 endingPage "2432" @default.
• W2904647658 startingPage "2424" @default.
• W2904647658 abstract "Abstract Purpose: Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin, an insulin sensitizer, reduces endometrial tumor growth in vitro. Presurgical window studies allow rapid in vivo assessment of antitumor activity. Previous window studies found metformin reduced endometrial cancer proliferation but these lacked methodological rigor. PREMIUM measured the anti-proliferative effect of metformin in vivo using a robust window study design. Patients and Methods: A multicenter, double-blind, placebo-controlled trial randomized women with atypical hyperplasia or endometrioid endometrial cancer to receive metformin (850 mg daily for 3 days, and twice daily thereafter) or placebo for 1 to 5 weeks until surgery. The primary outcome was posttreatment IHC expression of Ki-67. Secondary outcomes investigated the effect of metformin on markers of the PI3K–Akt–mTOR and insulin signaling pathways and obesity. Results: Eighty-eight women received metformin (n = 45) or placebo (n = 43) and completed treatment. There was no overall difference in posttreatment Ki-67 between the metformin and placebo arms, in an ANCOVA analysis adjusting for baseline Ki-67 expression (mean difference −0.57%; 95% CI, −7.57%–6.42%; P = 0.87). Metformin did not affect expression of markers of the PI3K–Akt–mTOR or insulin signaling pathways, and did not result in weight loss. Conclusions: Short-term treatment with standard diabetic doses of metformin does not reduce tumor proliferation in women with endometrioid endometrial cancer awaiting hysterectomy. This study does not support a biological effect of metformin in endometrial cancer and casts doubt on its potential application in the primary and adjuvant treatment settings." @default.
• W2904647658 created "2018-12-22" @default.
• W2904647658 creator A5004332195 @default.
• W2904647658 creator A5008419054 @default.
• W2904647658 creator A5011418202 @default.
• W2904647658 creator A5012394870 @default.
• W2904647658 creator A5015762740 @default.
• W2904647658 creator A5021782713 @default.
• W2904647658 creator A5026862664 @default.
• W2904647658 creator A5048763179 @default.
• W2904647658 creator A5052764151 @default.
• W2904647658 creator A5052794626 @default.
• W2904647658 creator A5056537119 @default.
• W2904647658 creator A5060094132 @default.
• W2904647658 creator A5060780906 @default.
• W2904647658 creator A5073656291 @default.
• W2904647658 date "2019-04-15" @default.
• W2904647658 modified "2023-10-15" @default.
• W2904647658 title "PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial" @default.
• W2904647658 cites W1487922930 @default.
• W2904647658 cites W1969542174 @default.
• W2904647658 cites W1970614140 @default.
• W2904647658 cites W1978064355 @default.
• W2904647658 cites W1990879130 @default.
• W2904647658 cites W2003225436 @default.
• W2904647658 cites W2009190388 @default.
• W2904647658 cites W2009665800 @default.
• W2904647658 cites W2039905469 @default.
• W2904647658 cites W2066032552 @default.
• W2904647658 cites W2069593603 @default.
• W2904647658 cites W2108776415 @default.
• W2904647658 cites W2117739987 @default.
• W2904647658 cites W2123945948 @default.
• W2904647658 cites W2124764963 @default.
• W2904647658 cites W2125292576 @default.
• W2904647658 cites W2131180390 @default.
• W2904647658 cites W2148755064 @default.
• W2904647658 cites W2151962431 @default.
• W2904647658 cites W2173133541 @default.
• W2904647658 cites W2253016892 @default.
• W2904647658 cites W2288788281 @default.
• W2904647658 cites W2327800659 @default.
• W2904647658 cites W2509993590 @default.
• W2904647658 cites W2558156847 @default.
• W2904647658 cites W2561389966 @default.
• W2904647658 cites W2604417758 @default.
• W2904647658 cites W2769646213 @default.
• W2904647658 cites W2891855400 @default.
• W2904647658 cites W2908035663 @default.
• W2904647658 cites W4210989197 @default.
• W2904647658 doi "https://doi.org/10.1158/1078-0432.ccr-18-3339" @default.
• W2904647658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6586555" @default.
• W2904647658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30563932" @default.
• W2904647658 hasPublicationYear "2019" @default.
• W2904647658 type Work @default.
• W2904647658 sameAs 2904647658 @default.
• W2904647658 citedByCount "37" @default.
• W2904647658 countsByYear W29046476582019 @default.
• W2904647658 countsByYear W29046476582020 @default.
• W2904647658 countsByYear W29046476582021 @default.
• W2904647658 countsByYear W29046476582022 @default.
• W2904647658 countsByYear W29046476582023 @default.
• W2904647658 crossrefType "journal-article" @default.
• W2904647658 hasAuthorship W2904647658A5004332195 @default.
• W2904647658 hasAuthorship W2904647658A5008419054 @default.
• W2904647658 hasAuthorship W2904647658A5011418202 @default.
• W2904647658 hasAuthorship W2904647658A5012394870 @default.
• W2904647658 hasAuthorship W2904647658A5015762740 @default.
• W2904647658 hasAuthorship W2904647658A5021782713 @default.
• W2904647658 hasAuthorship W2904647658A5026862664 @default.
• W2904647658 hasAuthorship W2904647658A5048763179 @default.
• W2904647658 hasAuthorship W2904647658A5052764151 @default.
• W2904647658 hasAuthorship W2904647658A5052794626 @default.
• W2904647658 hasAuthorship W2904647658A5056537119 @default.
• W2904647658 hasAuthorship W2904647658A5060094132 @default.
• W2904647658 hasAuthorship W2904647658A5060780906 @default.
• W2904647658 hasAuthorship W2904647658A5073656291 @default.
• W2904647658 hasBestOaLocation W29046476581 @default.
• W2904647658 hasConcept C121608353 @default.
• W2904647658 hasConcept C126322002 @default.
• W2904647658 hasConcept C126894567 @default.
• W2904647658 hasConcept C134018914 @default.
• W2904647658 hasConcept C142724271 @default.
• W2904647658 hasConcept C143998085 @default.
• W2904647658 hasConcept C204787440 @default.
• W2904647658 hasConcept C27081682 @default.
• W2904647658 hasConcept C2777088508 @default.
• W2904647658 hasConcept C2779306644 @default.
• W2904647658 hasConcept C2780323712 @default.
• W2904647658 hasConcept C29456083 @default.
• W2904647658 hasConcept C55493867 @default.
• W2904647658 hasConcept C62478195 @default.
• W2904647658 hasConcept C71924100 @default.
• W2904647658 hasConcept C86554907 @default.
• W2904647658 hasConcept C86803240 @default.
• W2904647658 hasConceptScore W2904647658C121608353 @default.
• W2904647658 hasConceptScore W2904647658C126322002 @default.
• W2904647658 hasConceptScore W2904647658C126894567 @default.

• next