FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904648082> ?p ?o ?g. }

• W2904648082 abstract "This study evaluated the proportion of patients with atherosclerotic cardiovascular disease (ASCVD) and probable heterozygous familial hypercholesterolemia (HeFH) achieving ≥50% reduction in low-density lipoprotein cholesterol (LDL-C) or reaching the LDL-C ≤70 mg/dL threshold, after initiating or modifying statin, and/or ezetimibe therapy.Adult ASCVD patients with baseline LDL-C >70 mg/dL (index) and a subset of patients with probable HeFH (proxied by LDL-C ≥190 mg/dL) were identified between January 1, 2012, and August 31, 2014, from the IQVIA electronic medical record database. Patients were followed for 12 months pre-index to examine baseline lipid-lowering therapy (LLT) use, and 12 months post index to evaluate treatment modifications and post-treatment LDL-C levels, stratified by type of treatment received and LDL-C levels at baseline.Of the sample of ASCVD patients who initiated treatment post-index (n=111,147), only 7.6% patients achieved a ≥50% reduction from baseline LDL-C and 19.1% of patients reached the LDL-C ≤70 mg/dL threshold. Among treated ASCVD patients who modified therapy post-index (n=75,523), 5.6% achieved a ≥50% reduction in LDL-C, and proportion of patients achieving LDL-C ≤70 mg/dL ranged from 6.9% to 26.7%, depending on the baseline LDL-C levels. Approximately 50% of the untreated probable HeFH patients (n=3,064) initiated LLT; however, the mean (SD) post-treatment LDL-C remained high (136.2 [47.8] mg/dL), with only 4.4% reaching LDL-C ≤70 mg/dL. Of the treated probable HeFH patients (n=1,073), 41.5% modified treatment; 22.1% achieved a ≥50% reduction in LDL-C and 1.1% reached LDL-C ≤70 mg/dL.This study found that most patients had suboptimal LDL-C responses after initiating or modifying standard LLT (statin and/or ezetimibe). More frequent and aggressive lipid management, including increasing statin intensity and alternative therapies, may be needed in patients with ASCVD and probable HeFH to reduce their cardiovascular risk." @default.
• W2904648082 created "2018-12-22" @default.
• W2904648082 creator A5004354044 @default.
• W2904648082 creator A5016771354 @default.
• W2904648082 creator A5042508373 @default.
• W2904648082 creator A5054726198 @default.
• W2904648082 creator A5060567239 @default.
• W2904648082 creator A5064922783 @default.
• W2904648082 date "2018-12-01" @default.
• W2904648082 modified "2023-09-27" @default.
• W2904648082 title "Low-density lipoprotein cholesterol outcomes post-non-PCSK9i lipid-lowering therapies in atherosclerotic cardiovascular disease and probable heterozygous familial hypercholesterolemia patients" @default.
• W2904648082 cites W1506880006 @default.
• W2904648082 cites W1535043470 @default.
• W2904648082 cites W1972054549 @default.
• W2904648082 cites W1991429317 @default.
• W2904648082 cites W2001328643 @default.
• W2904648082 cites W2005945277 @default.
• W2904648082 cites W2014667837 @default.
• W2904648082 cites W2019071303 @default.
• W2904648082 cites W2040170118 @default.
• W2904648082 cites W2057828023 @default.
• W2904648082 cites W2061747167 @default.
• W2904648082 cites W2066719367 @default.
• W2904648082 cites W2111099202 @default.
• W2904648082 cites W2121513836 @default.
• W2904648082 cites W2143003213 @default.
• W2904648082 cites W2161253919 @default.
• W2904648082 cites W2319057797 @default.
• W2904648082 cites W2402427708 @default.
• W2904648082 cites W2509676484 @default.
• W2904648082 cites W2605597981 @default.
• W2904648082 cites W2607031541 @default.
• W2904648082 cites W2725826768 @default.
• W2904648082 cites W2736069450 @default.
• W2904648082 cites W4236673002 @default.
• W2904648082 cites W4238251256 @default.
• W2904648082 cites W4238580056 @default.
• W2904648082 cites W630612001 @default.
• W2904648082 doi "https://doi.org/10.2147/tcrm.s180783" @default.
• W2904648082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6296203" @default.
• W2904648082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30587999" @default.
• W2904648082 hasPublicationYear "2018" @default.
• W2904648082 type Work @default.
• W2904648082 sameAs 2904648082 @default.
• W2904648082 citedByCount "2" @default.
• W2904648082 countsByYear W29046480822019 @default.
• W2904648082 crossrefType "journal-article" @default.
• W2904648082 hasAuthorship W2904648082A5004354044 @default.
• W2904648082 hasAuthorship W2904648082A5016771354 @default.
• W2904648082 hasAuthorship W2904648082A5042508373 @default.
• W2904648082 hasAuthorship W2904648082A5054726198 @default.
• W2904648082 hasAuthorship W2904648082A5060567239 @default.
• W2904648082 hasAuthorship W2904648082A5064922783 @default.
• W2904648082 hasBestOaLocation W29046480821 @default.
• W2904648082 hasConcept C126322002 @default.
• W2904648082 hasConcept C2776839432 @default.
• W2904648082 hasConcept C2778163477 @default.
• W2904648082 hasConcept C2778657065 @default.
• W2904648082 hasConcept C2779120738 @default.
• W2904648082 hasConcept C2779134260 @default.
• W2904648082 hasConcept C2779620165 @default.
• W2904648082 hasConcept C2909478654 @default.
• W2904648082 hasConcept C3019550498 @default.
• W2904648082 hasConcept C71924100 @default.
• W2904648082 hasConcept C90924648 @default.
• W2904648082 hasConceptScore W2904648082C126322002 @default.
• W2904648082 hasConceptScore W2904648082C2776839432 @default.
• W2904648082 hasConceptScore W2904648082C2778163477 @default.
• W2904648082 hasConceptScore W2904648082C2778657065 @default.
• W2904648082 hasConceptScore W2904648082C2779120738 @default.
• W2904648082 hasConceptScore W2904648082C2779134260 @default.
• W2904648082 hasConceptScore W2904648082C2779620165 @default.
• W2904648082 hasConceptScore W2904648082C2909478654 @default.
• W2904648082 hasConceptScore W2904648082C3019550498 @default.
• W2904648082 hasConceptScore W2904648082C71924100 @default.
• W2904648082 hasConceptScore W2904648082C90924648 @default.
• W2904648082 hasLocation W29046480821 @default.
• W2904648082 hasLocation W29046480822 @default.
• W2904648082 hasLocation W29046480823 @default.
• W2904648082 hasLocation W29046480824 @default.
• W2904648082 hasOpenAccess W2904648082 @default.
• W2904648082 hasPrimaryLocation W29046480821 @default.
• W2904648082 hasRelatedWork W2024930123 @default.
• W2904648082 hasRelatedWork W2030996923 @default.
• W2904648082 hasRelatedWork W2072946225 @default.
• W2904648082 hasRelatedWork W2150251354 @default.
• W2904648082 hasRelatedWork W2264476074 @default.
• W2904648082 hasRelatedWork W2400730210 @default.
• W2904648082 hasRelatedWork W2408098635 @default.
• W2904648082 hasRelatedWork W2904648082 @default.
• W2904648082 hasRelatedWork W3198702738 @default.
• W2904648082 hasRelatedWork W4200296051 @default.
• W2904648082 isParatext "false" @default.
• W2904648082 isRetracted "false" @default.
• W2904648082 magId "2904648082" @default.
• W2904648082 workType "article" @default.