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• W2904650247 abstract "Fructose consumption has increased because of widespread use of high-fructose corn syrup by the food industry. Renal proximal tubules are thought to reabsorb fructose. However, fructose reabsorption (J fructose ) by proximal tubules has not yet been directly demonstrated, nor the effects of dietary fructose on J fructose . This segment expresses Na + - and glucose-linked transporters (SGLTs) 1, 2, 4, and 5 and glucose transporters (GLUTs) 2 and 5. SGLT4 and -5 transport fructose, but SGLT1 and -2 do not. Knocking out SGLT5 increases urinary fructose excretion. We hypothesize that J fructose in the S2 portion of the proximal tubule is mediated by luminal entry via SGLT4/5 and basolateral exit by GLUT2 and that it is enhanced by a fructose-enriched diet. We measured J fructose by proximal straight tubules from rats consuming either tap water (Controls) or 20% fructose (FRU). Basal J fructose in Controls was 14.1 ± 1.5 pmol·mm −1 ·min −1 . SGLT inhibition with phlorizin reduced J fructose to 4.9 ± 1.4 pmol·mm −1 ·min −1 ( P < 0.008), whereas removal of Na + diminished J fructose by 86 ± 5% ( P < 0.0001). A fructose-enriched diet increased J fructose from 12.8 ± 2.5 to 19.3 ± 0.5 pmol·mm −1 ·min −1 , a 51% increase ( P < 0.03). Using immunofluorescence, we detected luminal SGLT4 and SGLT5 and basolateral GLUT2; GLUT5 was undetectable. The expression of apical transporters SGLT4 and SGLT5 was higher in FRU than in Controls [137 ± 10% ( P < 0.01) and 38 ± 14% ( P < 0.04), respectively]. GLUT2 was also elevated by 88 ± 27% ( P < 0.02) in FRU. We conclude that J fructose by proximal tubules occurs primarily via Na + -linked cotransport processes, and a fructose-enriched diet enhances reabsorption. Transport across luminal and basolateral membranes is likely mediated by SGLT4/5 and GLUT2, respectively." @default.
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• W2904650247 date "2019-03-01" @default.
• W2904650247 modified "2023-10-16" @default.
• W2904650247 title "Fructose reabsorption by rat proximal tubules: role of Na⁺-linked cotransporters and the effect of dietary fructose" @default.
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• W2904650247 doi "https://doi.org/10.1152/ajprenal.00247.2018" @default.
• W2904650247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459303" @default.
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