Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904654873> ?p ?o ?g. }
- W2904654873 endingPage "2962.e3" @default.
- W2904654873 startingPage "2955" @default.
- W2904654873 abstract "Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations overexpressing the DUX4 double homeodomain cause B cell leukemia. Here, we report the crystal structure of the tandem homeodomains of DUX4 bound to DNA. The homeodomains bind DNA in a head-to-head fashion, with the linker making anchoring DNA minor-groove interactions and unique protein contacts. Remarkably, despite being tandem duplicates, the DUX4 homeodomains recognize different core sequences. This results from an arginine-to-glutamate mutation, unique to primates, causing alternative positioning of a key arginine side chain in the recognition helix. Mutational studies demonstrate that this primate-specific change is responsible for the divergence in sequence recognition that likely drove coevolution of embryonically regulated repeats in primates. Our work provides a framework for understanding the endogenous function of DUX4 and its role in FSHD and cancer." @default.
- W2904654873 created "2018-12-22" @default.
- W2904654873 creator A5020544005 @default.
- W2904654873 creator A5023886416 @default.
- W2904654873 creator A5037168073 @default.
- W2904654873 creator A5056554657 @default.
- W2904654873 creator A5058149977 @default.
- W2904654873 creator A5064099494 @default.
- W2904654873 creator A5064298275 @default.
- W2904654873 creator A5068138213 @default.
- W2904654873 creator A5035616908 @default.
- W2904654873 creator A5085290113 @default.
- W2904654873 date "2018-12-01" @default.
- W2904654873 modified "2023-10-10" @default.
- W2904654873 title "Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA" @default.
- W2904654873 cites W1514532595 @default.
- W2904654873 cites W1833766276 @default.
- W2904654873 cites W1925430508 @default.
- W2904654873 cites W1944302200 @default.
- W2904654873 cites W1986748430 @default.
- W2904654873 cites W2004689349 @default.
- W2904654873 cites W2005286540 @default.
- W2904654873 cites W2013560484 @default.
- W2904654873 cites W2017035463 @default.
- W2904654873 cites W2017040061 @default.
- W2904654873 cites W2017826157 @default.
- W2904654873 cites W2022736304 @default.
- W2904654873 cites W2026556066 @default.
- W2904654873 cites W2037761873 @default.
- W2904654873 cites W2048546181 @default.
- W2904654873 cites W2055787369 @default.
- W2904654873 cites W2072361742 @default.
- W2904654873 cites W2076849893 @default.
- W2904654873 cites W2079199547 @default.
- W2904654873 cites W2081357269 @default.
- W2904654873 cites W2082127114 @default.
- W2904654873 cites W2099408708 @default.
- W2904654873 cites W2103091788 @default.
- W2904654873 cites W2117961940 @default.
- W2904654873 cites W2124026197 @default.
- W2904654873 cites W2136204966 @default.
- W2904654873 cites W2148515217 @default.
- W2904654873 cites W2163341755 @default.
- W2904654873 cites W2166810199 @default.
- W2904654873 cites W2180229411 @default.
- W2904654873 cites W2264988134 @default.
- W2904654873 cites W2294583975 @default.
- W2904654873 cites W2325206931 @default.
- W2904654873 cites W2335147237 @default.
- W2904654873 cites W2508999286 @default.
- W2904654873 cites W2535017817 @default.
- W2904654873 cites W2611165465 @default.
- W2904654873 cites W2611346822 @default.
- W2904654873 cites W2611929604 @default.
- W2904654873 cites W2754730404 @default.
- W2904654873 cites W2792479842 @default.
- W2904654873 cites W2883939342 @default.
- W2904654873 cites W4248872320 @default.
- W2904654873 doi "https://doi.org/10.1016/j.celrep.2018.11.060" @default.
- W2904654873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6463520" @default.
- W2904654873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30540931" @default.
- W2904654873 hasPublicationYear "2018" @default.
- W2904654873 type Work @default.
- W2904654873 sameAs 2904654873 @default.
- W2904654873 citedByCount "24" @default.
- W2904654873 countsByYear W29046548732019 @default.
- W2904654873 countsByYear W29046548732020 @default.
- W2904654873 countsByYear W29046548732021 @default.
- W2904654873 countsByYear W29046548732022 @default.
- W2904654873 countsByYear W29046548732023 @default.
- W2904654873 crossrefType "journal-article" @default.
- W2904654873 hasAuthorship W2904654873A5020544005 @default.
- W2904654873 hasAuthorship W2904654873A5023886416 @default.
- W2904654873 hasAuthorship W2904654873A5035616908 @default.
- W2904654873 hasAuthorship W2904654873A5037168073 @default.
- W2904654873 hasAuthorship W2904654873A5056554657 @default.
- W2904654873 hasAuthorship W2904654873A5058149977 @default.
- W2904654873 hasAuthorship W2904654873A5064099494 @default.
- W2904654873 hasAuthorship W2904654873A5064298275 @default.
- W2904654873 hasAuthorship W2904654873A5068138213 @default.
- W2904654873 hasAuthorship W2904654873A5085290113 @default.
- W2904654873 hasBestOaLocation W29046548731 @default.
- W2904654873 hasConcept C104317684 @default.
- W2904654873 hasConcept C121587040 @default.
- W2904654873 hasConcept C54355233 @default.
- W2904654873 hasConcept C552990157 @default.
- W2904654873 hasConcept C61342607 @default.
- W2904654873 hasConcept C86339819 @default.
- W2904654873 hasConcept C86803240 @default.
- W2904654873 hasConcept C95444343 @default.
- W2904654873 hasConceptScore W2904654873C104317684 @default.
- W2904654873 hasConceptScore W2904654873C121587040 @default.
- W2904654873 hasConceptScore W2904654873C54355233 @default.
- W2904654873 hasConceptScore W2904654873C552990157 @default.
- W2904654873 hasConceptScore W2904654873C61342607 @default.
- W2904654873 hasConceptScore W2904654873C86339819 @default.
- W2904654873 hasConceptScore W2904654873C86803240 @default.
- W2904654873 hasConceptScore W2904654873C95444343 @default.