FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904672290> ?p ?o ?g. }

• W2904672290 abstract "What is Known and Objective Pemetrexed/carboplatin combination chemotherapy has shown efficacy as a first-line treatment for advanced non-small-cell lung cancer. However, severe haematotoxicity is often observed during this combination chemotherapy. Some studies have suggested that concomitant drugs may be the risk factors for severe adverse events. However, those studies identified the predictive risk factors without paying attention to the relative dose intensities (RDIs) of the anticancer drugs. The objective of this study was to clarify the effects of concomitant drugs on the severe haematotoxicity induced by pemetrexed/carboplatin combination chemotherapy using multiple logistic regression analysis incorporating RDIs of the anticancer drugs. Methods We retrospectively reviewed the records of 61 patients who had received first-line treatment with this combination chemotherapy at Yamato Municipal Hospital between April 2011 and May 2017. Severe haematotoxicity was defined as grade 3 or 4 according to the Common Terminology Criteria for Adverse Events, version 4.0. To clarify the influence of concomitant drugs on haematotoxicity, we performed multiple logistic regression analysis. Results Among the 61 patients, 18 (29.5%) developed grade 3 or 4 haematotoxicity. Multiple logistic regression analysis showed that body weight <54.5 kg [odds ratio: 5.21, 95% confidence interval (CI): 1.17-23.08, P = 0.030], haemoglobin <12.0 g/dL [odds ratio: 7.13, 95% CI: 1.54-33.11, P = 0.012], and coadministration of proton pump inhibitors (PPIs) [odds ratio: 5.34, 95% CI: 1.06-26.94, P = 0.042] were significantly associated with severe haematotoxicity in patients receiving pemetrexed/carboplatin combination chemotherapy after adjustment using non-steroidal anti-inflammatory drugs and RDIs of the anticancer drugs. What is New and Conclusion Multiple logistic regression analysis incorporating RDIs of the anticancer drugs revealed that low baseline body weight, low baseline haemoglobin level, and coadministration of PPIs were the independent risk factors for predicting severe haematotoxicity induced by pemetrexed/carboplatin combination chemotherapy." @default.
• W2904672290 created "2018-12-22" @default.
• W2904672290 creator A5013776748 @default.
• W2904672290 creator A5021805035 @default.
• W2904672290 creator A5029965819 @default.
• W2904672290 creator A5048855875 @default.
• W2904672290 creator A5074931251 @default.
• W2904672290 creator A5091859532 @default.
• W2904672290 date "2018-12-15" @default.
• W2904672290 modified "2023-09-27" @default.
• W2904672290 title "Effects of proton pump inhibitors on severe haematotoxicity induced after first course of pemetrexed/carboplatin combination chemotherapy" @default.
• W2904672290 cites W1444601816 @default.
• W2904672290 cites W1550111394 @default.
• W2904672290 cites W1933587402 @default.
• W2904672290 cites W1998277689 @default.
• W2904672290 cites W2014672695 @default.
• W2904672290 cites W2069191600 @default.
• W2904672290 cites W2073875673 @default.
• W2904672290 cites W2099725888 @default.
• W2904672290 cites W2103282042 @default.
• W2904672290 cites W2106664438 @default.
• W2904672290 cites W2116996913 @default.
• W2904672290 cites W2121823208 @default.
• W2904672290 cites W2124011326 @default.
• W2904672290 cites W2127405377 @default.
• W2904672290 cites W2149804121 @default.
• W2904672290 cites W2151090489 @default.
• W2904672290 cites W2152189242 @default.
• W2904672290 cites W2161255934 @default.
• W2904672290 cites W2170134215 @default.
• W2904672290 cites W2504479633 @default.
• W2904672290 cites W2583353844 @default.
• W2904672290 cites W4301003819 @default.
• W2904672290 doi "https://doi.org/10.1111/jcpt.12788" @default.
• W2904672290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30552862" @default.
• W2904672290 hasPublicationYear "2018" @default.
• W2904672290 type Work @default.
• W2904672290 sameAs 2904672290 @default.
• W2904672290 citedByCount "2" @default.
• W2904672290 countsByYear W29046722902022 @default.
• W2904672290 countsByYear W29046722902023 @default.
• W2904672290 crossrefType "journal-article" @default.
• W2904672290 hasAuthorship W2904672290A5013776748 @default.
• W2904672290 hasAuthorship W2904672290A5021805035 @default.
• W2904672290 hasAuthorship W2904672290A5029965819 @default.
• W2904672290 hasAuthorship W2904672290A5048855875 @default.
• W2904672290 hasAuthorship W2904672290A5074931251 @default.
• W2904672290 hasAuthorship W2904672290A5091859532 @default.
• W2904672290 hasBestOaLocation W29046722901 @default.
• W2904672290 hasConcept C126322002 @default.
• W2904672290 hasConcept C141071460 @default.
• W2904672290 hasConcept C143998085 @default.
• W2904672290 hasConcept C151956035 @default.
• W2904672290 hasConcept C156957248 @default.
• W2904672290 hasConcept C197934379 @default.
• W2904672290 hasConcept C2776694085 @default.
• W2904672290 hasConcept C2777240266 @default.
• W2904672290 hasConcept C2777793932 @default.
• W2904672290 hasConcept C2778239845 @default.
• W2904672290 hasConcept C2779384505 @default.
• W2904672290 hasConcept C2781451048 @default.
• W2904672290 hasConcept C44249647 @default.
• W2904672290 hasConcept C71924100 @default.
• W2904672290 hasConceptScore W2904672290C126322002 @default.
• W2904672290 hasConceptScore W2904672290C141071460 @default.
• W2904672290 hasConceptScore W2904672290C143998085 @default.
• W2904672290 hasConceptScore W2904672290C151956035 @default.
• W2904672290 hasConceptScore W2904672290C156957248 @default.
• W2904672290 hasConceptScore W2904672290C197934379 @default.
• W2904672290 hasConceptScore W2904672290C2776694085 @default.
• W2904672290 hasConceptScore W2904672290C2777240266 @default.
• W2904672290 hasConceptScore W2904672290C2777793932 @default.
• W2904672290 hasConceptScore W2904672290C2778239845 @default.
• W2904672290 hasConceptScore W2904672290C2779384505 @default.
• W2904672290 hasConceptScore W2904672290C2781451048 @default.
• W2904672290 hasConceptScore W2904672290C44249647 @default.
• W2904672290 hasConceptScore W2904672290C71924100 @default.
• W2904672290 hasLocation W29046722901 @default.
• W2904672290 hasLocation W29046722902 @default.
• W2904672290 hasOpenAccess W2904672290 @default.
• W2904672290 hasPrimaryLocation W29046722901 @default.
• W2904672290 hasRelatedWork W1607236184 @default.
• W2904672290 hasRelatedWork W1975425037 @default.
• W2904672290 hasRelatedWork W2013653877 @default.
• W2904672290 hasRelatedWork W2091707360 @default.
• W2904672290 hasRelatedWork W2569260518 @default.
• W2904672290 hasRelatedWork W2608966496 @default.
• W2904672290 hasRelatedWork W2613556418 @default.
• W2904672290 hasRelatedWork W2802659363 @default.
• W2904672290 hasRelatedWork W2904672290 @default.
• W2904672290 hasRelatedWork W4293214742 @default.
• W2904672290 isParatext "false" @default.
• W2904672290 isRetracted "false" @default.
• W2904672290 magId "2904672290" @default.
• W2904672290 workType "article" @default.