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• W2904678146 abstract "Regorafenib exposure could potentially be influenced by an interaction with acid‐reducing drugs. In this crossover trial, patients were randomized into two sequence groups consisting of three phases: regorafenib intake alone, regorafenib with concomitant esomeprazole, and regorafenib with esomeprazole 3 hours prior. The primary end point was the relative difference ( RD ) in geometric means for regorafenib 0–24‐hour area under the concentration‐time curve ( AUC 0–24h ) and was analyzed by a linear mixed model in 14 patients. AUC 0–24h for regorafenib alone was 55.9 μg·hour/mL (coefficient of variance ( CV ): 40%), and for regorafenib with concomitant esomeprazole or with esomeprazole 3 hours prior AUC 0–24h was 53.7 μg·hour/mL ( CV : 34%) and 53.6 μg·hour/mL ( CV : 43%), respectively. No significant differences were identified when regorafenib alone was compared with regorafenib with concomitant esomeprazole ( RD : −3.9%; 95% confidence interval ( CI ): −20.5 to 16.1%; P = 1.0) or regorafenib with esomeprazole 3 hours prior ( RD : −4.1%; 95% CI : −22.8 to 19.2%; P = 1.0). These findings indicate that regorafenib and esomeprazole can be safely combined in clinical practice." @default.
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• W2904678146 date "2019-02-10" @default.
• W2904678146 modified "2023-10-18" @default.
• W2904678146 title "Influence of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib: A Randomized Crossover Pharmacokinetic Study" @default.
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• W2904678146 doi "https://doi.org/10.1002/cpt.1331" @default.
• W2904678146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593619" @default.
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