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- W2904681632 abstract "CRISPR and its associated proteins that are called, the CRISPR-Cas systems, confers adaptive immunity against exogenic elements in many bacteria and also most archaea. Unlike the restriction modification system that provides a defense against any foreign DNA lacking a protective methyl-tag in the target site, the CRISPR-Cas systems are invader-specific, adaptive, and heritable. This immunity is gained by integrating short fragments of foreign DNA into CRISPR loci. CRISPR-derived transcripts assemble with Cas proteins to target similar foreign nucleic acids for degradation. Moreover, in recent years investigation of anti-CRISPR proteins has provided important new insight into CRISPR-Cas systems. Here we review an update on the development and the applications of CRISPR-Cas systems and discuss the potential of these phage-resistance machineries." @default.
- W2904681632 created "2018-12-22" @default.
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- W2904681632 date "2019-01-01" @default.
- W2904681632 modified "2023-09-23" @default.
- W2904681632 title "Overview development and applications of CRISPR-Cas systems after a decade of research with a glance at anti-CRISPR proteins" @default.
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- W2904681632 doi "https://doi.org/10.1097/mrm.0000000000000153" @default.
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