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- W2904683725 abstract "The effects of cholesterol on the process of intrinsic lipidation, whereby an acyl chain is transferred from a lipid as donor to a membrane-associated acceptor molecule, have been explored using melittin as the acceptor. Membranes comprising lipids with saturated acyl chains (1,2-dipalmitoyl sn-glycero-3-phosphocholine, DPPC; 1,2-dimyristoyl sn-glycero-3-phosphocholine, DMPC) yielded no acyl transfer, whereas membranes composed of lipids with unsaturated acyl chains (1,2-dioleoyl sn-glycero-3-phosphocholine, DOPC; 1-palmitoyl-2-oleoyl sn-glycero-3-phosphocholine, POPC) produced detectable lipidation activity. For all lipids, inclusion of cholesterol led to a significant increase in lipidation activity, with the greatest effect observed for 20 mol% cholesterol in POPC. In the case of membranes composed of POPC, the inclusion of cholesterol also produced small changes in the selectivity for transfer from the sn-1 vs. sn-2 positions of the lipid. Qualitatively, for fluid membranes, the trend in lipidation activity exhibits a positive correlation with the bending modulus of the bilayer and is accounted for in terms of the penetration depth of the peptide. Access of water to reactive intermediates also has the potential to influence lipidation rates." @default.
- W2904683725 created "2018-12-22" @default.
- W2904683725 creator A5002625228 @default.
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- W2904683725 date "2019-01-01" @default.
- W2904683725 modified "2023-10-09" @default.
- W2904683725 title "The influence of cholesterol on melittin lipidation in neutral membranes" @default.
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- W2904683725 cites W1973642094 @default.
- W2904683725 cites W1977396733 @default.
- W2904683725 cites W1977428485 @default.
- W2904683725 cites W1977733457 @default.
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- W2904683725 cites W1989417741 @default.
- W2904683725 cites W1990016062 @default.
- W2904683725 cites W1993016109 @default.
- W2904683725 cites W1994174267 @default.
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- W2904683725 cites W2003537344 @default.
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- W2904683725 doi "https://doi.org/10.1039/c8cp06661b" @default.
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