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- W2904685632 abstract "Neurons have limited intracellular energy stores but experience acute and unpredictable increases in energy demand. To better understand how these cells repeatedly transit from a resting to active state without undergoing metabolic stress, we monitored their early metabolic response to neurotransmission using ion-sensitive probes and FRET sensors in vitro and in vivo. A short theta burst triggered immediate Na+ entry, followed by a delayed stimulation of the Na+/K+ ATPase pump. Unexpectedly, cytosolic ATP and ADP levels were unperturbed across a wide range of physiological workloads, revealing strict flux coupling between the Na+ pump and mitochondria. Metabolic flux measurements revealed a priming phase of mitochondrial energization by pyruvate, whereas glucose consumption coincided with delayed Na+ pump stimulation. Experiments revealed that the Na+ pump plays a permissive role for mitochondrial ATP production and glycolysis. We conclude that neuronal energy homeostasis is not mediated by adenine nucleotides or by Ca2+, but by a mechanism commanded by the Na+ pump." @default.
- W2904685632 created "2018-12-22" @default.
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- W2904685632 date "2019-03-01" @default.
- W2904685632 modified "2023-10-12" @default.
- W2904685632 title "Non-Canonical Control of Neuronal Energy Status by the Na+ Pump" @default.
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- W2904685632 doi "https://doi.org/10.1016/j.cmet.2018.11.005" @default.
- W2904685632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30527744" @default.
- W2904685632 hasPublicationYear "2019" @default.
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