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- W2904687098 abstract "Amac: Ovaryan hiperstimulasyon sendromu (OHSS) riski altindaki hastalarda, anjiotensin donusturucu enzim (ACE) gen insersiyon / delesyon (I/D) polimorfiziminin ovaryan hiperstimulasyon sendromu gelisiminde etkisinin olup olmadiginin belirlenmesidir. Gerec ve yontem: Yardimci ureme teknikleri tedavisi icin ovulasyon induksiyon programina alinan, ve human koryonik gonadotropin yapildigi gun estradiol seviyesi 3000 pg/ml’den fazla olan, OHSS gelisimi icin yuksek risk altinda bulunan 47 infertil hasta dahil edildi. Hastalarin yasi, infertilite suresi, kullanilan total gonadotropin dozu, induksiyon suresi, elde edilen folikul sayisi, endometriyum kalinligi ve infertilite nedeni kaydedildi. Kontrol (n:25) ve OHSS (n:22) grubu hastalarinin ACE genine ait insersiyon/delesyon polimorfizmi, PCR yontemiyle calisilarak tesbit edildi. Bulgular: Yas, infertilite suresi, gonadotropin dozu, induksiyon suresi, endometriyum kalinlik olcumleri iki grup arasinda anlamli farklilik gostermedi. Folikul sayisi kontrol grubunda 17,1 ± 4,2 OHSS grubunda 25,4 ± 6,8 olarak bulundu. Her iki grup arasinda bulunan fark anlamlidir ( p 0,05 ). OHSS grubunda genotipin DD olma olasiligi, kontrol grubuna gore 1,47 kat daha yuksektir (OR: 1,47 %95 Guven Siniri, 0,44-4,86) fakat istatistiksel olarak anlamli degildir. Sonuc: Calismada OHSS icin yuksek riskli hastalarda ACE gen insersiyon/delesyon polimorfizmi calisilmistir. DD genotipinin orani OHSS ve kontrol grubunda farkli degildir. ACE gen insersiyon/delesyon polimorfizminin, OHSS gelisiminde etken faktor olarak degerlendirilmemistir." @default.
- W2904687098 created "2018-12-22" @default.
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- W2904687098 date "2019-01-01" @default.
- W2904687098 modified "2023-09-25" @default.
- W2904687098 title "Ovaryan hipersimulasyon sendromlu hastalarda anjiotensin dönüştürücü enzim geni insersiyon / delesyon polimorfizmi" @default.
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