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- W2904692746 abstract "A simple synthetic route to access racemic 3,3-disubstituted propylamines in excellent yields (up to 95%) via Lewis acid catalyzed SN2-type ring opening of activated azetidines with electron-rich arenes and heteroarenes under mild conditions has been accomplished. The methodology is efficiently used for the racemic synthesis of an antimuscarinic drug, tolterodine, in four steps in 47% overall yield." @default.
- W2904692746 created "2018-12-22" @default.
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- W2904692746 date "2018-12-18" @default.
- W2904692746 modified "2023-09-25" @default.
- W2904692746 title "Synthesis of 3,3-Diaryl/Heteroarylpropylamines via Nucleophilic Ring Opening of Activated Azetidines with Arenes and Heteroarenes: New Synthetic Route to (±)Tolterodine" @default.
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- W2904692746 doi "https://doi.org/10.1021/acsomega.8b02487" @default.
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