Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904705904> ?p ?o ?g. }
- W2904705904 endingPage "202" @default.
- W2904705904 startingPage "190" @default.
- W2904705904 abstract "Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on tumour-derived EVs remain unclear. Here we show that two classes of cytotoxic drugs broadly employed in pre-operative (neoadjuvant) breast cancer therapy, taxanes and anthracyclines, elicit tumour-derived EVs with enhanced pro-metastatic capacity. Chemotherapy-elicited EVs are enriched in annexin A6 (ANXA6), a Ca2+-dependent protein that promotes NF-κB-dependent endothelial cell activation, Ccl2 induction and Ly6C+CCR2+ monocyte expansion in the pulmonary pre-metastatic niche to facilitate the establishment of lung metastasis. Genetic inactivation of Anxa6 in cancer cells or Ccr2 in host cells blunts the pro-metastatic effects of chemotherapy-elicited EVs. ANXA6 is detected, and potentially enriched, in the circulating EVs of breast cancer patients undergoing neoadjuvant chemotherapy." @default.
- W2904705904 created "2018-12-22" @default.
- W2904705904 creator A5001087662 @default.
- W2904705904 creator A5002407601 @default.
- W2904705904 creator A5008466376 @default.
- W2904705904 creator A5011597628 @default.
- W2904705904 creator A5015585176 @default.
- W2904705904 creator A5018738915 @default.
- W2904705904 creator A5025353193 @default.
- W2904705904 creator A5034972183 @default.
- W2904705904 creator A5039961461 @default.
- W2904705904 creator A5040173992 @default.
- W2904705904 creator A5043563746 @default.
- W2904705904 creator A5050674652 @default.
- W2904705904 creator A5050962688 @default.
- W2904705904 creator A5053920842 @default.
- W2904705904 creator A5054965207 @default.
- W2904705904 creator A5069797655 @default.
- W2904705904 creator A5073221843 @default.
- W2904705904 creator A5076591587 @default.
- W2904705904 creator A5077976858 @default.
- W2904705904 date "2018-12-31" @default.
- W2904705904 modified "2023-10-14" @default.
- W2904705904 title "Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models" @default.
- W2904705904 cites W1504464770 @default.
- W2904705904 cites W1551407310 @default.
- W2904705904 cites W1601681275 @default.
- W2904705904 cites W1769783081 @default.
- W2904705904 cites W1877686344 @default.
- W2904705904 cites W1883024731 @default.
- W2904705904 cites W1901372019 @default.
- W2904705904 cites W1908116487 @default.
- W2904705904 cites W1932669647 @default.
- W2904705904 cites W1940048983 @default.
- W2904705904 cites W1950118853 @default.
- W2904705904 cites W1963904011 @default.
- W2904705904 cites W1979751563 @default.
- W2904705904 cites W1982276721 @default.
- W2904705904 cites W1982441587 @default.
- W2904705904 cites W1994344811 @default.
- W2904705904 cites W1998261391 @default.
- W2904705904 cites W2001740805 @default.
- W2904705904 cites W2005134188 @default.
- W2904705904 cites W2006550410 @default.
- W2904705904 cites W2006951895 @default.
- W2904705904 cites W2010291889 @default.
- W2904705904 cites W2017056838 @default.
- W2904705904 cites W2019315324 @default.
- W2904705904 cites W2027654614 @default.
- W2904705904 cites W2058085109 @default.
- W2904705904 cites W2061687333 @default.
- W2904705904 cites W2075419121 @default.
- W2904705904 cites W2084304742 @default.
- W2904705904 cites W2087179076 @default.
- W2904705904 cites W2089258206 @default.
- W2904705904 cites W2111449140 @default.
- W2904705904 cites W2115394351 @default.
- W2904705904 cites W2120621109 @default.
- W2904705904 cites W2143839116 @default.
- W2904705904 cites W2145261833 @default.
- W2904705904 cites W2154971346 @default.
- W2904705904 cites W2158062858 @default.
- W2904705904 cites W2163035374 @default.
- W2904705904 cites W2170852633 @default.
- W2904705904 cites W2171549753 @default.
- W2904705904 cites W2259481044 @default.
- W2904705904 cites W2261862398 @default.
- W2904705904 cites W2296538017 @default.
- W2904705904 cites W2318433546 @default.
- W2904705904 cites W2344732859 @default.
- W2904705904 cites W2508312148 @default.
- W2904705904 cites W2529551101 @default.
- W2904705904 cites W2555906390 @default.
- W2904705904 cites W2567639438 @default.
- W2904705904 cites W2594569109 @default.
- W2904705904 cites W2594599876 @default.
- W2904705904 cites W2596133050 @default.
- W2904705904 cites W2649656222 @default.
- W2904705904 cites W2744433299 @default.
- W2904705904 cites W2763910757 @default.
- W2904705904 cites W2772615438 @default.
- W2904705904 cites W2775714010 @default.
- W2904705904 cites W2786004990 @default.
- W2904705904 cites W2786514708 @default.
- W2904705904 cites W2791748877 @default.
- W2904705904 cites W2792356144 @default.
- W2904705904 cites W2801901889 @default.
- W2904705904 cites W2818713708 @default.
- W2904705904 cites W4234586755 @default.
- W2904705904 doi "https://doi.org/10.1038/s41556-018-0256-3" @default.
- W2904705904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6525097" @default.
- W2904705904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30598531" @default.
- W2904705904 hasPublicationYear "2018" @default.
- W2904705904 type Work @default.
- W2904705904 sameAs 2904705904 @default.
- W2904705904 citedByCount "353" @default.
- W2904705904 countsByYear W29047059042019 @default.
- W2904705904 countsByYear W29047059042020 @default.