Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904717791> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2904717791 endingPage "492" @default.
- W2904717791 startingPage "483" @default.
- W2904717791 abstract "The study aims to investigate the effect of aqueous fruit pulp of Dialium guineense on hemeoxygenase, and insulin release, inhibition of angiotensin converting enzyme (ACE) and possible hypoglycemia in streptozotocin-induced diabetic rats. Twenty four male Wistar rats were grouped into control, diabetic (Dm), diabetic + 300 mg/kg body weight Dialium guineese (Dm+ DG) and diabetic + 100 mg/kg metformin (Dm +MET). Apart from the control, other rats were made diabetic by a single dose of 50 mg/kg streptozotocin injected intraperitoneally. Dialium and metformin were administered orally three days after induction of diabetes. Result showed significant (p<0.01) increase in serum ACE, blood glucose, and a decrease (p<0.01) in HO-1 and insulin in the Dm group. There was also an increase (p<0.01) in TC, TG and LDL-c. Tissue peroxidation (Heart and Kidney) was high in the diabetic untreated rats, superoxide dismutase and catalase activity was attenuated. Administration of aqueous fruit pulp and metformin significantly (p<0.001) increased HO-1 and insulin secretion, decreased ACE and blood sugar level (p<0.001) as well as the TC, TG and LDL-c. Antioxidant activities in the kidney and liver were potentiated. In conclusion, this study showed that Dialium guineese fruit pulp enhances HO-1 and insulin release and inhibits ACE activity. It is hypoglycemic, hypolipidemic and evokes antioxidant activity.Key words: Hemeoxygenase-1 (HO-1), angiotensin converting enzyme (ACE), insulin, diabetes, Dialium guineese, metformin." @default.
- W2904717791 created "2018-12-22" @default.
- W2904717791 creator A5013728007 @default.
- W2904717791 creator A5057592367 @default.
- W2904717791 creator A5073240074 @default.
- W2904717791 date "2018-11-25" @default.
- W2904717791 modified "2023-09-30" @default.
- W2904717791 title "In vivo efficacy of Dialium guineense fruit pulp on hemeoxygenase-1 and angiotensin converting enzyme in experimental diabetes" @default.
- W2904717791 cites W1978856846 @default.
- W2904717791 cites W2000118672 @default.
- W2904717791 cites W2029186987 @default.
- W2904717791 cites W2045081700 @default.
- W2904717791 cites W2046007343 @default.
- W2904717791 cites W2059467226 @default.
- W2904717791 cites W2062450294 @default.
- W2904717791 cites W2063934588 @default.
- W2904717791 cites W2064508323 @default.
- W2904717791 cites W2096795975 @default.
- W2904717791 cites W2097784879 @default.
- W2904717791 cites W2098421398 @default.
- W2904717791 cites W2115872207 @default.
- W2904717791 cites W2129702858 @default.
- W2904717791 cites W2151949890 @default.
- W2904717791 cites W2315436410 @default.
- W2904717791 doi "https://doi.org/10.5897/jmpr2018.6670" @default.
- W2904717791 hasPublicationYear "2018" @default.
- W2904717791 type Work @default.
- W2904717791 sameAs 2904717791 @default.
- W2904717791 citedByCount "0" @default.
- W2904717791 crossrefType "journal-article" @default.
- W2904717791 hasAuthorship W2904717791A5013728007 @default.
- W2904717791 hasAuthorship W2904717791A5057592367 @default.
- W2904717791 hasAuthorship W2904717791A5073240074 @default.
- W2904717791 hasBestOaLocation W29047177911 @default.
- W2904717791 hasConcept C126322002 @default.
- W2904717791 hasConcept C134018914 @default.
- W2904717791 hasConcept C185592680 @default.
- W2904717791 hasConcept C2778004101 @default.
- W2904717791 hasConcept C2779280383 @default.
- W2904717791 hasConcept C2779306644 @default.
- W2904717791 hasConcept C2780323712 @default.
- W2904717791 hasConcept C55493867 @default.
- W2904717791 hasConcept C555293320 @default.
- W2904717791 hasConcept C71924100 @default.
- W2904717791 hasConceptScore W2904717791C126322002 @default.
- W2904717791 hasConceptScore W2904717791C134018914 @default.
- W2904717791 hasConceptScore W2904717791C185592680 @default.
- W2904717791 hasConceptScore W2904717791C2778004101 @default.
- W2904717791 hasConceptScore W2904717791C2779280383 @default.
- W2904717791 hasConceptScore W2904717791C2779306644 @default.
- W2904717791 hasConceptScore W2904717791C2780323712 @default.
- W2904717791 hasConceptScore W2904717791C55493867 @default.
- W2904717791 hasConceptScore W2904717791C555293320 @default.
- W2904717791 hasConceptScore W2904717791C71924100 @default.
- W2904717791 hasIssue "28" @default.
- W2904717791 hasLocation W29047177911 @default.
- W2904717791 hasOpenAccess W2904717791 @default.
- W2904717791 hasPrimaryLocation W29047177911 @default.
- W2904717791 hasRelatedWork W1978360972 @default.
- W2904717791 hasRelatedWork W1982371325 @default.
- W2904717791 hasRelatedWork W1985743555 @default.
- W2904717791 hasRelatedWork W2020929702 @default.
- W2904717791 hasRelatedWork W2029177283 @default.
- W2904717791 hasRelatedWork W2033313326 @default.
- W2904717791 hasRelatedWork W2140173719 @default.
- W2904717791 hasRelatedWork W2142392245 @default.
- W2904717791 hasRelatedWork W2168119070 @default.
- W2904717791 hasRelatedWork W50098970 @default.
- W2904717791 hasVolume "12" @default.
- W2904717791 isParatext "false" @default.
- W2904717791 isRetracted "false" @default.
- W2904717791 magId "2904717791" @default.
- W2904717791 workType "article" @default.