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- W2904752436 endingPage "670" @default.
- W2904752436 startingPage "657" @default.
- W2904752436 abstract "Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination of benzene. The effectiveness of this dearomatization approach is notable, as only two additional olefin functionalizations are needed to construct the fully decorated aminocyclitol cores of these alkaloids. Installation of the lactam ring has been achieved through several pathways and a direct interconversion between natural products was established via a late-stage C-7 cupration. Using this synthetic blueprint, we were able to produce natural products on a gram scale and provide tailored analogs with improved activity, solubility, and metabolic stability." @default.
- W2904752436 created "2018-12-22" @default.
- W2904752436 creator A5001091783 @default.
- W2904752436 creator A5009999197 @default.
- W2904752436 creator A5015611835 @default.
- W2904752436 creator A5027996458 @default.
- W2904752436 creator A5046889544 @default.
- W2904752436 creator A5058389691 @default.
- W2904752436 date "2018-12-06" @default.
- W2904752436 modified "2023-10-12" @default.
- W2904752436 title "Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene" @default.
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