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- W2904752777 abstract "Esophageal and gastric cancers represent tumors with poor prognosis. Unfortunately, radiotherapy, chemotherapy, and targeted therapy have made only limited progress in recent years in improving the generally disappointing outcome. Immunotherapy with checkpoint inhibitors is a novel treatment approach that quickly entered clinical practice in malignant melanoma and renal cell cancer, but the role in esophageal and gastric cancer is still poorly defined. The principal prognostic/predictive biomarkers for immunotherapy efficacy currently considered are PD-L1 expression along with defects in mismatch repair genes resulting in microsatellite instability (MSI-H) phenotype. The new molecular classification of gastric cancer also takes these factors into consideration. Available reports regarding PD-1, PD-L1, PD-L2 expression and MSI status in gastric and esophageal cancer are reviewed to summarize the clinical prognostic and predictive role together with potential clinical implications. The most important recently published clinical trials evaluating checkpoint inhibitor efficacy in these tumors are also summarized." @default.
- W2904752777 created "2018-12-22" @default.
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- W2904752777 date "2018-12-20" @default.
- W2904752777 modified "2023-09-30" @default.
- W2904752777 title "From Tumor Immunology to Immunotherapy in Gastric and Esophageal Cancer" @default.
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- W2904752777 doi "https://doi.org/10.3390/ijms20010013" @default.
- W2904752777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337592" @default.
- W2904752777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30577521" @default.
- W2904752777 hasPublicationYear "2018" @default.
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