FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904753338> ?p ?o ?g. }

• W2904753338 endingPage "501" @default.
• W2904753338 startingPage "501" @default.
• W2904753338 abstract "Marine biotoxins in fish and shellfish can cause several symptoms in consumers, such as diarrhea, amnesia, or even death by paralysis. Monitoring programs are in place for testing shellfish on a regular basis. In some countries testing is performed using the so-called mouse bioassay, an assay that faces ethical concerns not only because of animal distress, but also because it lacks specificity and results in high amounts of false positives. In Europe, for lipophilic marine biotoxins (LMBs), a chemical analytical method using LC-MS/MS was developed as an alternative and is now the reference method. However, safety is often questioned when relying solely on such a method, and as a result, the mouse bioassay might still be used. In this study the use of a cell-based assay for screening, i.e., the neuro-2a assay, in combination with the official LC-MS/MS method was investigated as a new alternative strategy for the detection and quantification of LMBs. To this end, samples that had been tested previously with the mouse bioassay were analyzed in the neuro-2a bioassay and the LC-MS/MS method. The neuro-2a bioassay was able to detect all LMBs at the regulatory levels and all samples that tested positive in the mouse bioassay were also suspect in the neuro-2a bioassay. In most cases, these samples contained toxin levels (yessotoxins) that explain the outcome of the bioassay but did not exceed the established maximum permitted levels." @default.
• W2904753338 created "2018-12-22" @default.
• W2904753338 creator A5001138315 @default.
• W2904753338 creator A5011162290 @default.
• W2904753338 creator A5024589017 @default.
• W2904753338 creator A5033733890 @default.
• W2904753338 creator A5035684771 @default.
• W2904753338 creator A5044310469 @default.
• W2904753338 creator A5076027029 @default.
• W2904753338 creator A5083118080 @default.
• W2904753338 date "2018-12-12" @default.
• W2904753338 modified "2023-10-16" @default.
• W2904753338 title "A Strategy to Replace the Mouse Bioassay for Detecting and Identifying Lipophilic Marine Biotoxins by Combining the Neuro-2a Bioassay and LC-MS/MS Analysis" @default.
• W2904753338 cites W172977155 @default.
• W2904753338 cites W2017966955 @default.
• W2904753338 cites W2030337749 @default.
• W2904753338 cites W2043204083 @default.
• W2904753338 cites W2066855623 @default.
• W2904753338 cites W2077715615 @default.
• W2904753338 cites W2078455499 @default.
• W2904753338 cites W2078471877 @default.
• W2904753338 cites W2078478904 @default.
• W2904753338 cites W2089311376 @default.
• W2904753338 cites W2093741825 @default.
• W2904753338 cites W2105649871 @default.
• W2904753338 cites W2155333187 @default.
• W2904753338 cites W2155489721 @default.
• W2904753338 cites W2158922561 @default.
• W2904753338 cites W2332267823 @default.
• W2904753338 cites W2337715038 @default.
• W2904753338 cites W2394782692 @default.
• W2904753338 cites W2465706717 @default.
• W2904753338 cites W2495434472 @default.
• W2904753338 cites W2751546256 @default.
• W2904753338 cites W2901615244 @default.
• W2904753338 doi "https://doi.org/10.3390/md16120501" @default.
• W2904753338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6315780" @default.
• W2904753338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30545061" @default.
• W2904753338 hasPublicationYear "2018" @default.
• W2904753338 type Work @default.
• W2904753338 sameAs 2904753338 @default.
• W2904753338 citedByCount "13" @default.
• W2904753338 countsByYear W29047533382020 @default.
• W2904753338 countsByYear W29047533382021 @default.
• W2904753338 countsByYear W29047533382022 @default.
• W2904753338 countsByYear W29047533382023 @default.
• W2904753338 crossrefType "journal-article" @default.
• W2904753338 hasAuthorship W2904753338A5001138315 @default.
• W2904753338 hasAuthorship W2904753338A5011162290 @default.
• W2904753338 hasAuthorship W2904753338A5024589017 @default.
• W2904753338 hasAuthorship W2904753338A5033733890 @default.
• W2904753338 hasAuthorship W2904753338A5035684771 @default.
• W2904753338 hasAuthorship W2904753338A5044310469 @default.
• W2904753338 hasAuthorship W2904753338A5076027029 @default.
• W2904753338 hasAuthorship W2904753338A5083118080 @default.
• W2904753338 hasBestOaLocation W29047533381 @default.
• W2904753338 hasConcept C104488531 @default.
• W2904753338 hasConcept C119857082 @default.
• W2904753338 hasConcept C158278297 @default.
• W2904753338 hasConcept C185592680 @default.
• W2904753338 hasConcept C18903297 @default.
• W2904753338 hasConcept C2777367657 @default.
• W2904753338 hasConcept C2777646408 @default.
• W2904753338 hasConcept C2779792404 @default.
• W2904753338 hasConcept C2781028344 @default.
• W2904753338 hasConcept C2909208804 @default.
• W2904753338 hasConcept C2910844273 @default.
• W2904753338 hasConcept C33070731 @default.
• W2904753338 hasConcept C41008148 @default.
• W2904753338 hasConcept C43617362 @default.
• W2904753338 hasConcept C505870484 @default.
• W2904753338 hasConcept C64869954 @default.
• W2904753338 hasConcept C86803240 @default.
• W2904753338 hasConcept C89423630 @default.
• W2904753338 hasConceptScore W2904753338C104488531 @default.
• W2904753338 hasConceptScore W2904753338C119857082 @default.
• W2904753338 hasConceptScore W2904753338C158278297 @default.
• W2904753338 hasConceptScore W2904753338C185592680 @default.
• W2904753338 hasConceptScore W2904753338C18903297 @default.
• W2904753338 hasConceptScore W2904753338C2777367657 @default.
• W2904753338 hasConceptScore W2904753338C2777646408 @default.
• W2904753338 hasConceptScore W2904753338C2779792404 @default.
• W2904753338 hasConceptScore W2904753338C2781028344 @default.
• W2904753338 hasConceptScore W2904753338C2909208804 @default.
• W2904753338 hasConceptScore W2904753338C2910844273 @default.
• W2904753338 hasConceptScore W2904753338C33070731 @default.
• W2904753338 hasConceptScore W2904753338C41008148 @default.
• W2904753338 hasConceptScore W2904753338C43617362 @default.
• W2904753338 hasConceptScore W2904753338C505870484 @default.
• W2904753338 hasConceptScore W2904753338C64869954 @default.
• W2904753338 hasConceptScore W2904753338C86803240 @default.
• W2904753338 hasConceptScore W2904753338C89423630 @default.
• W2904753338 hasFunder F4320321780 @default.
• W2904753338 hasIssue "12" @default.
• W2904753338 hasLocation W29047533381 @default.
• W2904753338 hasLocation W29047533382 @default.
• W2904753338 hasLocation W29047533383 @default.
• W2904753338 hasLocation W29047533384 @default.

• next