Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904756489> ?p ?o ?g. }
- W2904756489 endingPage "1944" @default.
- W2904756489 startingPage "1944" @default.
- W2904756489 abstract "Children with phenylketonuria (PKU) follow a protein restricted diet with negligible amounts of docosahexaenoic acid (DHA). Low DHA intakes might explain subtle neurological deficits in PKU. We studied whether a DHA supply modified plasma DHA and neurological and intellectual functioning in PKU. In a double-blind multicentric trial, 109 PKU patients were randomized to DHA doses from 0 to 7 mg/kg&day for six months. Before and after supplementation, we determined plasma fatty acid concentrations, latencies of visually evoked potentials, fine and gross motor behavior, and IQ. Fatty acid desaturase genotypes were also determined. DHA supplementation increased plasma glycerophospholipid DHA proportional to dose by 0.4% DHA per 1 mg intake/kg bodyweight. Functional outcomes were not associated with DHA status before and after intervention and remained unchanged by supplementation. Genotypes were associated with plasma arachidonic acid levels and, if considered together with the levels of the precursor alpha-linolenic acid, also with DHA. Functional outcomes and supplementation effects were not significantly associated with genotype. DHA intakes up to 7 mg/kg did not improve neurological functions in PKU children. Nervous tissues may be less prone to low DHA levels after infancy, or higher doses might be required to impact neurological functions. In situations of minimal dietary DHA, endogenous synthesis of DHA from alpha-linolenic acid could relevantly contribute to DHA status." @default.
- W2904756489 created "2018-12-22" @default.
- W2904756489 creator A5005743183 @default.
- W2904756489 creator A5008702206 @default.
- W2904756489 creator A5016900720 @default.
- W2904756489 creator A5022733778 @default.
- W2904756489 creator A5029637170 @default.
- W2904756489 creator A5031198707 @default.
- W2904756489 creator A5032923173 @default.
- W2904756489 creator A5048169226 @default.
- W2904756489 creator A5051869966 @default.
- W2904756489 creator A5058347774 @default.
- W2904756489 creator A5066308509 @default.
- W2904756489 creator A5073283699 @default.
- W2904756489 creator A5077404268 @default.
- W2904756489 creator A5085656006 @default.
- W2904756489 creator A5087618628 @default.
- W2904756489 date "2018-12-07" @default.
- W2904756489 modified "2023-10-05" @default.
- W2904756489 title "Determinants of Plasma Docosahexaenoic Acid Levels and Their Relationship to Neurological and Cognitive Functions in PKU Patients: A Double Blind Randomized Supplementation Study" @default.
- W2904756489 cites W1543301511 @default.
- W2904756489 cites W179888430 @default.
- W2904756489 cites W1852583464 @default.
- W2904756489 cites W1926187054 @default.
- W2904756489 cites W1964554927 @default.
- W2904756489 cites W1965336624 @default.
- W2904756489 cites W1980692505 @default.
- W2904756489 cites W1984645499 @default.
- W2904756489 cites W1985890220 @default.
- W2904756489 cites W1990091159 @default.
- W2904756489 cites W1995242140 @default.
- W2904756489 cites W1996071127 @default.
- W2904756489 cites W2002551925 @default.
- W2904756489 cites W2002919801 @default.
- W2904756489 cites W2007503700 @default.
- W2904756489 cites W2007624828 @default.
- W2904756489 cites W2026175790 @default.
- W2904756489 cites W2027410966 @default.
- W2904756489 cites W2029928645 @default.
- W2904756489 cites W2044948389 @default.
- W2904756489 cites W2045104435 @default.
- W2904756489 cites W2045950538 @default.
- W2904756489 cites W2051648756 @default.
- W2904756489 cites W2052453925 @default.
- W2904756489 cites W2052559156 @default.
- W2904756489 cites W2060313074 @default.
- W2904756489 cites W2061240655 @default.
- W2904756489 cites W2062555905 @default.
- W2904756489 cites W2064320740 @default.
- W2904756489 cites W2077978112 @default.
- W2904756489 cites W2080278790 @default.
- W2904756489 cites W2086685655 @default.
- W2904756489 cites W2089116690 @default.
- W2904756489 cites W2090485520 @default.
- W2904756489 cites W2094091797 @default.
- W2904756489 cites W2094853920 @default.
- W2904756489 cites W2095595424 @default.
- W2904756489 cites W2095999777 @default.
- W2904756489 cites W2097969728 @default.
- W2904756489 cites W2103045933 @default.
- W2904756489 cites W2104285446 @default.
- W2904756489 cites W2112864443 @default.
- W2904756489 cites W2115826909 @default.
- W2904756489 cites W2118528443 @default.
- W2904756489 cites W2120491838 @default.
- W2904756489 cites W2120549104 @default.
- W2904756489 cites W2133998561 @default.
- W2904756489 cites W2134416501 @default.
- W2904756489 cites W2158369256 @default.
- W2904756489 cites W2163145309 @default.
- W2904756489 cites W2170504439 @default.
- W2904756489 cites W2194575735 @default.
- W2904756489 cites W2343330228 @default.
- W2904756489 cites W2468592655 @default.
- W2904756489 cites W2473706804 @default.
- W2904756489 cites W2513976484 @default.
- W2904756489 cites W2557048977 @default.
- W2904756489 cites W2734927163 @default.
- W2904756489 cites W2768718524 @default.
- W2904756489 cites W2771245739 @default.
- W2904756489 cites W334455586 @default.
- W2904756489 cites W414781422 @default.
- W2904756489 cites W4243281984 @default.
- W2904756489 cites W4246450878 @default.
- W2904756489 doi "https://doi.org/10.3390/nu10121944" @default.
- W2904756489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6316534" @default.
- W2904756489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30544518" @default.
- W2904756489 hasPublicationYear "2018" @default.
- W2904756489 type Work @default.
- W2904756489 sameAs 2904756489 @default.
- W2904756489 citedByCount "11" @default.
- W2904756489 countsByYear W29047564892019 @default.
- W2904756489 countsByYear W29047564892020 @default.
- W2904756489 countsByYear W29047564892021 @default.
- W2904756489 countsByYear W29047564892022 @default.
- W2904756489 countsByYear W29047564892023 @default.
- W2904756489 crossrefType "journal-article" @default.
- W2904756489 hasAuthorship W2904756489A5005743183 @default.