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- W2904759019 abstract "To investigate the effect of rituximab on microcirculation in long-term SSc.Four patients with diffuse SSc over 3 years of disease received rituximab cycles of two 1-g infusions every 6 months for 2 years. Videocapillaroscopy was performed at baseline, 12 months, and 24 months and semi-quantitative scoring of videocapillaroscopy abnormalities was performed and the microangiopathy evolution score (MES: range 0-9) was calculated. The mean disease duration was 5 years (range 3-15). On videocapillaroscopy, giant capillaries and hemorrhages remained stable from baseline to 24 months. Capillary loss, abnormally-shaped capillaries, and MES stabilized at 12 months and increased by 24.5% and 28% at 24 months. Rituximab improves microcirculation in long-term SSc. Stabilization and reduced progression of microcirculation abnormalities were achieved at 12 and 24 months, respectively." @default.
- W2904759019 created "2018-12-22" @default.
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- W2904759019 date "2018-12-01" @default.
- W2904759019 modified "2023-10-08" @default.
- W2904759019 title "Effects of treatment with rituximab on microcirculation in patients with long-term systemic sclerosis" @default.
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- W2904759019 doi "https://doi.org/10.1186/s13104-018-3994-1" @default.
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