FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904761750> ?p ?o ?g. }

• W2904761750 endingPage "108" @default.
• W2904761750 startingPage "89" @default.
• W2904761750 abstract "In this study, we evaluated the therapeutic efficacy of monoisoamyldimercaptosuccinic acid (MiADMSA) against individual and combined effects of arsenic (As) and lead (Pb) on the monoaminergic system and behavioral functions in rats. Pregnant rats were exposed to sodium metaarsenite (50 ppm) and lead acetate (0.2%) individually and in combination (As = 25 ppm + Pb = 0.1%) via drinking water from gestation day (GD) 6 to postnatal day (PND) 21. MiADMSA (50 mg/kg body weight) was given orally through gavage for 3 consecutive days to pups from PND 18 to PND 20. The results showed increases in synaptosomal epinephrine, dopamine, and norepinephrine levels with individual metal exposures and decreases with combined exposure to As and Pb in the cortex, cerebellum, and hippocampus in PND 21, PND 28, and 3 months age-group rats. We found decreased activity of mitochondrial monoamine oxidase in the selected brain regions following individual and combined exposures to Pb and As. In addition, rats treated with Pb and As alone or in combination showed significant deficits in open-field behavior, grip strength, locomotor activity, and exploratory behavior at PND 28 and 3 months of age. However, MiADMSA administration showed reversal effects against the As- and/or Pb-induced impairments in the monoaminergic system as well as in behavioral functions of rats. Our data demonstrated that the mixture of Pb and As induced synergistic toxicity to developing brain leading to impairments in neurobehavioral functions and also suggest therapeutic efficacy of MiADMSA against Pb- and/or As-induced developmental neurotoxicity." @default.
• W2904761750 created "2018-12-22" @default.
• W2904761750 creator A5018129450 @default.
• W2904761750 creator A5042952597 @default.
• W2904761750 creator A5045973470 @default.
• W2904761750 creator A5057524093 @default.
• W2904761750 date "2018-12-10" @default.
• W2904761750 modified "2023-10-18" @default.
• W2904761750 title "Effects of combined arsenic and lead exposure on the brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA" @default.
• W2904761750 cites W1514244157 @default.
• W2904761750 cites W1515393515 @default.
• W2904761750 cites W1571762451 @default.
• W2904761750 cites W1714700057 @default.
• W2904761750 cites W1781335978 @default.
• W2904761750 cites W1966167674 @default.
• W2904761750 cites W1981830850 @default.
• W2904761750 cites W1985031521 @default.
• W2904761750 cites W2006707551 @default.
• W2904761750 cites W2006729357 @default.
• W2904761750 cites W2014761741 @default.
• W2904761750 cites W2015940780 @default.
• W2904761750 cites W2025024553 @default.
• W2904761750 cites W2027307634 @default.
• W2904761750 cites W2028426227 @default.
• W2904761750 cites W2040328794 @default.
• W2904761750 cites W2050446307 @default.
• W2904761750 cites W2054237515 @default.
• W2904761750 cites W2054259100 @default.
• W2904761750 cites W2057104206 @default.
• W2904761750 cites W2061821538 @default.
• W2904761750 cites W2067279343 @default.
• W2904761750 cites W2072329197 @default.
• W2904761750 cites W2073633014 @default.
• W2904761750 cites W2078848109 @default.
• W2904761750 cites W2080601958 @default.
• W2904761750 cites W2083073005 @default.
• W2904761750 cites W2083551368 @default.
• W2904761750 cites W2084299492 @default.
• W2904761750 cites W2096228531 @default.
• W2904761750 cites W2113125109 @default.
• W2904761750 cites W2121946080 @default.
• W2904761750 cites W2133356175 @default.
• W2904761750 cites W2149776295 @default.
• W2904761750 cites W2150902758 @default.
• W2904761750 cites W2154781008 @default.
• W2904761750 cites W2161164932 @default.
• W2904761750 cites W2167136925 @default.
• W2904761750 cites W2169871350 @default.
• W2904761750 cites W2192529084 @default.
• W2904761750 cites W2294750714 @default.
• W2904761750 cites W2368485309 @default.
• W2904761750 cites W2413606534 @default.
• W2904761750 cites W2426071339 @default.
• W2904761750 cites W2437170195 @default.
• W2904761750 cites W2508758374 @default.
• W2904761750 cites W2509476325 @default.
• W2904761750 cites W2525666831 @default.
• W2904761750 cites W2548311355 @default.
• W2904761750 cites W2604133615 @default.
• W2904761750 cites W2730524918 @default.
• W2904761750 cites W4255282673 @default.
• W2904761750 doi "https://doi.org/10.1177/0748233718814990" @default.
• W2904761750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30526433" @default.
• W2904761750 hasPublicationYear "2018" @default.
• W2904761750 type Work @default.
• W2904761750 sameAs 2904761750 @default.
• W2904761750 citedByCount "16" @default.
• W2904761750 countsByYear W29047617502019 @default.
• W2904761750 countsByYear W29047617502020 @default.
• W2904761750 countsByYear W29047617502021 @default.
• W2904761750 countsByYear W29047617502022 @default.
• W2904761750 countsByYear W29047617502023 @default.
• W2904761750 crossrefType "journal-article" @default.
• W2904761750 hasAuthorship W2904761750A5018129450 @default.
• W2904761750 hasAuthorship W2904761750A5042952597 @default.
• W2904761750 hasAuthorship W2904761750A5045973470 @default.
• W2904761750 hasAuthorship W2904761750A5057524093 @default.
• W2904761750 hasConcept C126322002 @default.
• W2904761750 hasConcept C134018914 @default.
• W2904761750 hasConcept C170493617 @default.
• W2904761750 hasConcept C181199279 @default.
• W2904761750 hasConcept C185592680 @default.
• W2904761750 hasConcept C187714386 @default.
• W2904761750 hasConcept C2775864247 @default.
• W2904761750 hasConcept C2776024655 @default.
• W2904761750 hasConcept C2779085643 @default.
• W2904761750 hasConcept C2779224224 @default.
• W2904761750 hasConcept C2779491297 @default.
• W2904761750 hasConcept C2779652256 @default.
• W2904761750 hasConcept C2781161787 @default.
• W2904761750 hasConcept C29730261 @default.
• W2904761750 hasConcept C42251903 @default.
• W2904761750 hasConcept C513476851 @default.
• W2904761750 hasConcept C55493867 @default.
• W2904761750 hasConcept C71924100 @default.
• W2904761750 hasConceptScore W2904761750C126322002 @default.
• W2904761750 hasConceptScore W2904761750C134018914 @default.
• W2904761750 hasConceptScore W2904761750C170493617 @default.

• next