FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904762854> ?p ?o ?g. }

• W2904762854 endingPage "185" @default.
• W2904762854 startingPage "176" @default.
• W2904762854 abstract "Amyloid-beta 42 (Aβ42) aggregates represent a prominent histopathological feature in Alzheimer's disease (AD); thus, immunotherapy against oligomeric Aβ42 aggregates is considered to be a potentially safe and specific therapeutic strategy. In this study, we identified an anti-oligomeric Aβ42 aggregate single-chain variable fragment (scFv) antibody, HT6, that is capable of efficiently binding to medium-sized Aβ42 aggregates (mainly 18–45 kDa) in vitro with an equilibrium dissociation constant (KD) of 3.0 × 10–6 M, whether they were derived from Aβ42 monomer, larger Aβ42 oligomers, or even fibrils. This ability allowed scFv HT6 to induce the gradual disassembly of large Aβ42 aggregates into small Aβ42 oligomers while simultaneously effectively inhibiting the further development of Aβ42 aggregates. Moreover, the scFv HT6-targeted conformational region on Aβ42 aggregates was found to be more local and relatively close to the N-terminus of Aβ42; thus, scFv HT6 significantly delayed or even prevented the aggregation of Aβ42 protofibrils, while significantly reducing the cytotoxicity of Aβ42 oligomers. Overall, this study demonstrate that even though the decrease in the cytotoxicity of Aβ42 aggregates might be closely related to the reduction in Aβ42 aggregates and vice versa, the reduction in Aβ42 aggregates might not necessarily be accompanied by or followed by the reduction or even elimination of the cytotoxicity of Aβ42 aggregates. This insight enriches the diversity of anti-oligomeric Aβ42 antibodies, further providing a new understanding into the relationship between their binding pattern to Aβ42 aggregates and the efficacy against their formation, offering a therapeutic strategy to delay the progression of AD." @default.
• W2904762854 created "2018-12-22" @default.
• W2904762854 creator A5030086846 @default.
• W2904762854 creator A5043389551 @default.
• W2904762854 creator A5045143881 @default.
• W2904762854 creator A5060839698 @default.
• W2904762854 creator A5065752249 @default.
• W2904762854 date "2019-02-01" @default.
• W2904762854 modified "2023-10-16" @default.
• W2904762854 title "Novel antibody against oligomeric amyloid-β: Insight into factors for effectively reducing the aggregation and cytotoxicity of amyloid-β aggregates" @default.
• W2904762854 cites W1410152057 @default.
• W2904762854 cites W1525374648 @default.
• W2904762854 cites W1593949795 @default.
• W2904762854 cites W1705725530 @default.
• W2904762854 cites W1965351431 @default.
• W2904762854 cites W1973479349 @default.
• W2904762854 cites W1987888326 @default.
• W2904762854 cites W1994014218 @default.
• W2904762854 cites W2011467350 @default.
• W2904762854 cites W2023430392 @default.
• W2904762854 cites W2027050460 @default.
• W2904762854 cites W2038108326 @default.
• W2904762854 cites W2043477653 @default.
• W2904762854 cites W2055775253 @default.
• W2904762854 cites W2144098186 @default.
• W2904762854 cites W2148404862 @default.
• W2904762854 cites W2313725855 @default.
• W2904762854 cites W2587333264 @default.
• W2904762854 cites W2736908165 @default.
• W2904762854 cites W2753880461 @default.
• W2904762854 cites W2761268425 @default.
• W2904762854 cites W2770758719 @default.
• W2904762854 cites W2787612390 @default.
• W2904762854 cites W2790658037 @default.
• W2904762854 cites W2809078375 @default.
• W2904762854 cites W2810634108 @default.
• W2904762854 cites W3189076138 @default.
• W2904762854 doi "https://doi.org/10.1016/j.intimp.2018.12.014" @default.
• W2904762854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30553911" @default.
• W2904762854 hasPublicationYear "2019" @default.
• W2904762854 type Work @default.
• W2904762854 sameAs 2904762854 @default.
• W2904762854 citedByCount "11" @default.
• W2904762854 countsByYear W29047628542020 @default.
• W2904762854 countsByYear W29047628542021 @default.
• W2904762854 countsByYear W29047628542022 @default.
• W2904762854 countsByYear W29047628542023 @default.
• W2904762854 crossrefType "journal-article" @default.
• W2904762854 hasAuthorship W2904762854A5030086846 @default.
• W2904762854 hasAuthorship W2904762854A5043389551 @default.
• W2904762854 hasAuthorship W2904762854A5045143881 @default.
• W2904762854 hasAuthorship W2904762854A5060839698 @default.
• W2904762854 hasAuthorship W2904762854A5065752249 @default.
• W2904762854 hasConcept C109316439 @default.
• W2904762854 hasConcept C12554922 @default.
• W2904762854 hasConcept C136238340 @default.
• W2904762854 hasConcept C142724271 @default.
• W2904762854 hasConcept C159654299 @default.
• W2904762854 hasConcept C166940927 @default.
• W2904762854 hasConcept C178790620 @default.
• W2904762854 hasConcept C179104552 @default.
• W2904762854 hasConcept C185592680 @default.
• W2904762854 hasConcept C202751555 @default.
• W2904762854 hasConcept C203014093 @default.
• W2904762854 hasConcept C27523624 @default.
• W2904762854 hasConcept C2777633098 @default.
• W2904762854 hasConcept C2779134260 @default.
• W2904762854 hasConcept C2780642029 @default.
• W2904762854 hasConcept C2909607560 @default.
• W2904762854 hasConcept C2994168385 @default.
• W2904762854 hasConcept C3019447875 @default.
• W2904762854 hasConcept C521977710 @default.
• W2904762854 hasConcept C55493867 @default.
• W2904762854 hasConcept C71924100 @default.
• W2904762854 hasConcept C86803240 @default.
• W2904762854 hasConceptScore W2904762854C109316439 @default.
• W2904762854 hasConceptScore W2904762854C12554922 @default.
• W2904762854 hasConceptScore W2904762854C136238340 @default.
• W2904762854 hasConceptScore W2904762854C142724271 @default.
• W2904762854 hasConceptScore W2904762854C159654299 @default.
• W2904762854 hasConceptScore W2904762854C166940927 @default.
• W2904762854 hasConceptScore W2904762854C178790620 @default.
• W2904762854 hasConceptScore W2904762854C179104552 @default.
• W2904762854 hasConceptScore W2904762854C185592680 @default.
• W2904762854 hasConceptScore W2904762854C202751555 @default.
• W2904762854 hasConceptScore W2904762854C203014093 @default.
• W2904762854 hasConceptScore W2904762854C27523624 @default.
• W2904762854 hasConceptScore W2904762854C2777633098 @default.
• W2904762854 hasConceptScore W2904762854C2779134260 @default.
• W2904762854 hasConceptScore W2904762854C2780642029 @default.
• W2904762854 hasConceptScore W2904762854C2909607560 @default.
• W2904762854 hasConceptScore W2904762854C2994168385 @default.
• W2904762854 hasConceptScore W2904762854C3019447875 @default.
• W2904762854 hasConceptScore W2904762854C521977710 @default.
• W2904762854 hasConceptScore W2904762854C55493867 @default.
• W2904762854 hasConceptScore W2904762854C71924100 @default.
• W2904762854 hasConceptScore W2904762854C86803240 @default.
• W2904762854 hasFunder F4320327282 @default.

• next