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• W2904770012 endingPage "e0208829" @default.
• W2904770012 startingPage "e0208829" @default.
• W2904770012 abstract "Mitochondrial DNA (mtDNA) haplogroups (hgs) are evolutionarily conserved sets of mtDNA SNP-haplotypes with characteristic geographical distribution. Associations of hgs with disease and physiological characteristics have been reported, but have frequently not been reproducible. Using 418 mtDNA SNPs on the PsychChip (Illumina), we assessed the spatio-temporal distribution of mtDNA hgs in Denmark from DNA isolated from 24,642 geographically un-biased dried blood spots (DBS), collected from 1981 to 2005 through the Danish National Neonatal Screening program. ADMIXTURE was used to establish the genomic ancestry of all samples using a reference of 100K+ autosomal SNPs in 2,248 individuals from nine populations. Median-joining analysis determined that the hgs were highly variable, despite being typically Northern European in origin, suggesting multiple founder events. Furthermore, considerable heterogeneity and variation in nuclear genomic ancestry was observed. Thus, individuals with hg H exhibited 95%, and U hgs 38.2% - 92.5%, Danish ancestry. Significant clines between geographical regions and rural and metropolitan populations were found. Over 25 years, macro-hg L increased from 0.2% to 1.2% (p = 1.1*E-10), and M from 1% to 2.4% (p = 3.7*E-8). Hg U increased among the R macro-hg from 14.1% to 16.5% (p = 1.9*E-3). Genomic ancestry, geographical skewedness, and sub-hg distribution suggested that the L, M and U increases are due to immigration. The complex spatio-temporal dynamics and genomic ancestry of mtDNA in the Danish population reflect repeated migratory events and, in later years, net immigration. Such complexity may explain the often contradictory and population-specific reports of mito-genomic association with disease." @default.
• W2904770012 created "2018-12-22" @default.
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• W2904770012 date "2018-12-13" @default.
• W2904770012 modified "2023-10-13" @default.
• W2904770012 title "Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes" @default.
• W2904770012 cites W1493371020 @default.
• W2904770012 cites W1546375972 @default.
• W2904770012 cites W1760976735 @default.
• W2904770012 cites W1794628503 @default.
• W2904770012 cites W1834060250 @default.
• W2904770012 cites W1880166755 @default.
• W2904770012 cites W1923377817 @default.
• W2904770012 cites W1938364190 @default.
• W2904770012 cites W1966646192 @default.
• W2904770012 cites W1968952472 @default.
• W2904770012 cites W1969931826 @default.
• W2904770012 cites W1973925468 @default.
• W2904770012 cites W1974507197 @default.
• W2904770012 cites W1975758951 @default.
• W2904770012 cites W1980701758 @default.
• W2904770012 cites W1984301324 @default.
• W2904770012 cites W1986265706 @default.
• W2904770012 cites W1987954830 @default.
• W2904770012 cites W1989352711 @default.
• W2904770012 cites W1989669460 @default.
• W2904770012 cites W1999232243 @default.
• W2904770012 cites W2001072306 @default.
• W2904770012 cites W2001539492 @default.
• W2904770012 cites W2009756075 @default.
• W2904770012 cites W2012645980 @default.
• W2904770012 cites W2017035597 @default.
• W2904770012 cites W2017344012 @default.
• W2904770012 cites W2017347785 @default.
• W2904770012 cites W2018086090 @default.
• W2904770012 cites W2023402149 @default.
• W2904770012 cites W2026974730 @default.
• W2904770012 cites W2028092741 @default.
• W2904770012 cites W2035543772 @default.
• W2904770012 cites W2035790270 @default.
• W2904770012 cites W2037462254 @default.
• W2904770012 cites W2038810697 @default.
• W2904770012 cites W2039608769 @default.
• W2904770012 cites W2039873798 @default.
• W2904770012 cites W2039977047 @default.
• W2904770012 cites W2042581531 @default.
• W2904770012 cites W2046487105 @default.
• W2904770012 cites W2050211984 @default.
• W2904770012 cites W2050359667 @default.
• W2904770012 cites W2050403250 @default.
• W2904770012 cites W2050876420 @default.
• W2904770012 cites W2050967443 @default.
• W2904770012 cites W2057346879 @default.
• W2904770012 cites W2058517351 @default.
• W2904770012 cites W2064337222 @default.
• W2904770012 cites W2065449688 @default.
• W2904770012 cites W2071733040 @default.
• W2904770012 cites W2077414996 @default.
• W2904770012 cites W2078341440 @default.
• W2904770012 cites W2079829897 @default.
• W2904770012 cites W2088209114 @default.
• W2904770012 cites W2091017864 @default.
• W2904770012 cites W2092145305 @default.
• W2904770012 cites W2092155338 @default.
• W2904770012 cites W2093682552 @default.
• W2904770012 cites W2095233947 @default.
• W2904770012 cites W2095915630 @default.
• W2904770012 cites W2096420865 @default.
• W2904770012 cites W2096826261 @default.
• W2904770012 cites W2098151244 @default.
• W2904770012 cites W2101117598 @default.
• W2904770012 cites W2103468176 @default.
• W2904770012 cites W2104688201 @default.
• W2904770012 cites W2105056132 @default.
• W2904770012 cites W2105744572 @default.
• W2904770012 cites W2105754268 @default.
• W2904770012 cites W2106333948 @default.
• W2904770012 cites W2108169091 @default.
• W2904770012 cites W2108653966 @default.
• W2904770012 cites W2110740477 @default.

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