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- W2904770981 abstract "Abstract Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribution (rat PK) and have thus the potential to inhibit the PDE10A target in vivo at a lower efficacious dose than the reference compound WEB-3." @default.
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- W2904770981 date "2019-02-01" @default.
- W2904770981 modified "2023-09-23" @default.
- W2904770981 title "Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors." @default.
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- W2904770981 doi "https://doi.org/10.2210/pdb6msc/pdb" @default.
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